Publications by authors named "Tzu-Hsuan Ma"
Article Synopsis
- Eliminating core fucose from Fc antibody glycoforms can increase the efficacy of therapeutic antibodies, particularly enhancing ADCC, but traditional fucosidases have limitations in effectiveness.
- A newly identified α-l-fucosidase (fucA) from a bacterium shows high reactivity to specific fucose linkages while demonstrating robust stability and activity under various conditions.
- Using fucA in glycoengineering of the antibody adalimumab achieved efficient removal of core fucose, leading to a more effective afucosylated form with improved binding to Fcγ receptor IIIa.
Chembiochem
February 2024
Article Synopsis
- Hirudins are natural proteins that serve as anticoagulants by directly blocking thrombin, an important factor in blood coagulation.
- They mainly inhibit thrombin through interactions at both its active and regulatory sites, with sulfate groups on certain amino acids enhancing their binding.
- Research on synthesized hirudin peptides showed that adding sulfotyrosine or more negatively charged amino acids didn't significantly improve thrombin inhibition, even though one peptide showed better binding to thrombin.
