Publications by authors named "Tzu-Ching Hsu"
Int J Mol Sci
October 2021
Article Synopsis
- Group A Streptococcus (GAS) is a serious human pathogen linked to severe infections like necrotizing fasciitis and toxic shock syndrome, with high mortality rates despite antibiotic treatment.
- The compound AR-12 has shown potential in reducing GAS growth significantly and killing the bacteria within two hours by damaging their nucleic acids and proteins, as well as impacting their structure.
- AR-12, particularly in combination with gentamicin, demonstrated enhanced antibacterial effects in both lab studies and animal models, suggesting it could be an innovative treatment approach for invasive GAS infections.
