Synopsis of recent research by authors named "Tzu-Ching Chi"
- Tzu-Ching Chi's recent research focuses on the synthesis of multisubstituted 1,2,3-triazoles, emphasizing a regioselective formation method using β-carbonyl phosphonates and azides.
- The study demonstrates that 1,4- and 1,5-disubstituted and 1,4,5-trisubstituted triazoles can be achieved under mild conditions, yielding good to excellent results across 31 examples, with yields reaching up to 99%.
- A detailed reaction mechanism is proposed, detailing the selective avoidance of byproducts from the phosphonates, supported by crystallographic and experimental data, enhancing the understanding of triazole formation.
