Successful Perianal Wound Treatment Using the Fecal Management System: A Report of 2 Cases.

Background: Fecal diversion is important for healing of perianal wounds. However, traditional fecal diversion with colostomy is associated with risks of general anesthesia and requires healthy abdominal skin for stoma creation. Alternative methods of fecal diversion are needed.

Customized 3-Dimensional-Printed Finger Splints for Mallet Finger.

We aimed to evaluate the feasibility and effectiveness of customized 3-dimensional (3D)-printed finger splints in the treatment of mallet fingers. We categorized 21 patients into those who received the traditional finger splint (group A) and those treated with a customized 3D-printed finger splint (group B). We retrospectively analyzed the functional outcomes and patient satisfaction in the 2 groups.

Association between headache frequency and risk for fibromyalgia in patients with migraine.

Background: The present study aimed to evaluate the risk and impact of fibromyalgia in relation to headache frequency in migraine patients.

Methods: This cross-sectional study involved migraine patients from a regional hospital and a tertiary medical center. Diagnoses of migraine and fibromyalgia were made according to the International Classification of Headache Disorders, 3rd edition, and the modified 2016 American College of Rheumatology diagnostic criteria, respectively.

Time Allocation to Physical Activity and Sedentary Behaviour and Its Impact on Sarcopenia Risk: A Systematic Review and Meta-Analysis.

Aim: To evaluate the relationship between time spent in sedentary behaviour and physical activity and sarcopenia in older adults, and to analyse the effect of reallocating time between different intensities of activities on sarcopenia.

Design: Systematic review and meta-analysis.

Methods: Following PRISMA guidelines, data were synthesised using a random-effects model, with heterogeneity assessed via Cochran's Q test and the I statistic.

Exploring the impact of acute SARS-CoV-2 infection on headache pattern in patients with migraine: A novel Bayesian analysis.

Objectives: To analyze headache and migraine dynamics around severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Background: Headache is a common symptom of SARS-CoV-2 infection, which caused the coronavirus disease 2019 (COVID-19) pandemic. However, the daily changes in headache patterns in patients with migraine during the infection are unclear.

Association between early retirement and risk of frailty in later life: A population-based longitudinal study.

Aim: Early retirement is prevalent and can alter daily habits, potentially impacting health. This study aims to explore the association between early retirement and frailty and to examine the modifying effect of sociodemographic characteristics.

Methods: We conducted a population-based matched cohort study that included 1 779 628 early retirees aged 45-64 years and an equal number of employed individuals from Taiwan's National Health Insurance (2010-2021).

Contribution of the gonococcal gene conversion to the pathobiology of the urethritis clade, UC.

Over the last decade, a () urethritis-causing clade (UC) has emerged to cause clusters of meningococcal urethritis in the United States and globally. One genomic signature of UC is the integration of () DNA in an operon, , which partially replaced the gene. IspD is the 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase of the terpenoid precursor synthesis pathway, required for the production of ubiquinones of the electron transfer chain.

Progression of antibiotic resistance in .

SUMMARYThe human pathogen () is the causative agent of invasive meningococcal disease (IMD), usually presenting as meningitis, bacteremia, or sepsis. Unlike , antibiotic resistance in has developed slowly. However, in the last two decades and with the reemergence of IMD following the COVID-19 pandemic, antibiotic-resistant isolates, especially to penicillin and fluoroquinolones, have progressively increased.

Polyphenolic Hispolon Derived from Medicinal Mushrooms of the and Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments.

: This study investigated the wound-healing potential of hispolon, a polyphenolic pigment derived from medicinal mushrooms, under diabetic conditions using both in vitro and in vivo models. : In the in vitro assays, L929 fibroblast cells exposed to high glucose (33 mmol/L) were treated with hispolon at concentrations of 2.5, 5, 7.

Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis.

Background: Delirium is a common and severe condition among adult intensive care unit (ICU) patients. Music intervention, as a non-pharmacological approach, has the potential to reduce delirium, but the optimal dosage and type of intervention remain unclear.

Aim: To explore the effects of music intervention at different doses and types on reducing delirium in ICU patients.

Epitaxial Electrodeposition of Zinc on Different Single Crystal Copper Substrates for High Performance Aqueous Batteries.

The aqueous zinc metal battery holds great potential for large-scale energy storage due to its safety, low cost, and high theoretical capacity. However, challenges such as corrosion and dendritic growth necessitate controlled zinc deposition. This study employs epitaxy to achieve large-area, dense, and ultraflat zinc plating on textured copper foil.

The impact of age on comparative diagnostic accuracy of temporal artery thermometers and non-contact infrared thermometers for fever detection: a systematic review and meta-analysis.

Background: Non-invasive temporal artery thermometers (TATs) and non-contact infrared thermometers (NCITs) are increasingly used in community settings to measure body temperature. Existing research predominantly focuses on pediatric populations, yet the accuracy and precision of TATs and NCITs for fever screening across age groups remain unclear. This study aims to assess age-related differences in the diagnostic accuracy of TATs and NCITs for fever detection.

The Neisseria meningitidis urethritis clade (NmUC) acts as a "chimeric pathogen" during infection of primary, human male, urethral epithelial cells.

Background: Clusters of male urethritis cases, caused by a novel clade of non-groupable Neisseria meningitidis (NmUC, "the clade"), have been reported globally. Genetic features unique to NmUC isolates include: the acquisition of the gonococcal denitrification loci, norB-aniA; a unique factor H binding protein (fHbp) variant; and loss of group C capsule and intrinsic lipooligosaccharide sialylation. We hypothesized that these characteristics might confer a colonization and survival advantage to NmUC during male urethral infection relative to non-clade group C Neisseria meningitidis.

Effectiveness of an e-book in enhancing knowledge, coping behaviors and preventive strategies for sexual harassment prevention among new nurses: A randomized controlled study.

Aim: To evaluate the effectiveness of an interactive e-book in improving new nurses' knowledge, coping behaviors and preventive strategies for sexual harassment prevention, while also assessing its impact on learning motivation.

Background: Sexual harassment has a detrimental effect on nurses' physical and mental well-being, as well as on patient safety, with new nurses being particularly vulnerable.

Design: A single centre, randomized controlled study.

NHBA antibodies elicited by 4CMenB vaccination are key for serum bactericidal activity against Neisseria gonorrhoeae.

The 4CMenB (Bexsero) vaccine contains detergent-extracted outer membrane vesicles (OMVs) from a Neisseria meningitidis (Nm) group B strain NZ98/254 and three recombinant Nm protein antigens: Neisseria adhesin A (NadA), Factor H binding protein (FHbp, as the C-terminal protein in the GNA2091-FHbp fusion), and Neisserial Heparin Binding Antigen (NHBA, as the N-terminal protein in the NHBA-GNA1030 fusion). Previous work has shown that 4CMenB generates serum antibodies to Nm and Neisseria gonorrhoeae (Ng) OMV proteins and lipooligosaccharide (LOS). Mounting evidence indicates 4CMenB can partially protect against mucosal infections with Ng.

Impact of a newly implemented burn protocol at Tri-Service General Hospital: Outcome analysis of 20-year experience.

Purpose: To share our 20-year experience in major burn management and the impact of a newly implemented burn protocol since 2015 at Tri-Service General Hospital (TSGH).

Materials And Methods: We performed a retrospective cohort study of severely burned patients who were admitted to the intensive care unit (ICU) at TSGH from January 2003 to September 2023. Data regarding demographics, complications, and mortality were collected and analyzed.

Separate anterior paraventricular thalamus projections differentially regulate sensory and affective aspects of pain.

The experience of pain is complex, involving both sensory and affective components, yet the underlying neural mechanisms remain elusive. Here, we show that formalin-induced pain behaviors coincide with increased responses in glutamatergic neurons within the anterior paraventricular nucleus of the thalamus (PVA). Furthermore, we describe non-overlapping subpopulations of PVAVgluT2 neurons involved in sensory and affective pain processing, whose activity varies across different pain states.

Meta-analysis of deep learning approaches for automated coronary artery calcium scoring: Performance and clinical utility AI in CAC scoring: A meta-analysis: AI in CAC scoring: A meta-analysis.

Introduction: Manual Coronary Artery Calcium (CAC) scoring, crucial for assessing coronary artery disease risk, is time-consuming and variable. Deep learning, particularly through Convolutional Neural Networks (CNNs), promises to automate and enhance the accuracy of CAC scoring, which this study investigates.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search across PubMed, Embase, Web of Science, and IEEE databases from their inception until November 1, 2023, and selected studies that employed deep learning for automated CAC scoring.

Mobile Health-Based Health Literacy Weight Management Intervention Using Smart Devices for Adolescents: A Convergent Mixed-Methods Pilot Study.

This study aimed to develop and evaluate the feasibility of a mobile health-based health literacy weight management intervention program for adolescents during the COVID-19 pandemic. Therefore, a convergent mixed-method design was used. The "GO! GO! Smart Healthy" intervention development engaged multidisciplinary healthcare professionals, utilizing mobile health applications and smartwatches.

Idiopathic intracranial hypertension in Asians: a retrospective dual-center study.

Background: There have been limited data on idiopathic intracranial hypertension (IIH) in Asians and there remain uncertainties whether a cerebrospinal fluid (CSF) pressure of 250 mm CSF is an optimum diagnostic cutoff. The aims of the present study included (1) characterization of IIH patients in Taiwan, (2) comparisons among different diagnostic criteria for IIH, and (3) comparisons between patients with CSF pressures of > 250 and 200-250 mm CSF.

Methods: This retrospective study involved IIH patients based on the modified Dandy criteria from two tertiary medical centers in Taiwan.

Improving the creation of SiV centers in diamond via sub-μs pulsed annealing treatment.

Silicon-vacancy (SiV) centers in diamond are emerging as promising quantum emitters in applications such as quantum communication and quantum information processing. Here, we demonstrate a sub-μs pulsed annealing treatment that dramatically increases the photoluminescence of SiV centers in diamond. Using a silane-functionalized adamantane precursor and a laser-heated diamond anvil cell, the temperature and energy conditions required to form SiV centers in diamond were mapped out via an optical thermometry system with an accuracy of ±50 K and a 1 μs temporal resolution.