Synopsis of recent research by authors named "Tze-Ming Chan"
- Tze-Ming Chan's recent research spans the discovery and optimization of novel compounds, focusing on their pharmacological applications, particularly in developing inhibitors for various therapeutic targets such as γ-secretase, thrombin receptors, and PDE10, which are relevant in neurodegenerative diseases and cancer treatment.
- Significant findings include the development of potent thrombin receptor antagonists derived from nor-seco himbacine and the identification of pyrazoloquinoline analogs as PDE10 inhibitors that exhibit promising antipsychotic activities in animal models.
- Chan's work not only involves medicinal chemistry, synthesizing and characterizing new compounds but also employs advanced techniques like LC-MS and NMR for the rapid identification and structural elucidation of pharmaceutical impurities, enhancing the understanding of drug stability and efficacy.*
