Developing ROR1 Targeting CAR-T Cells against Solid Tumors in Preclinical Studies.

Chimeric antigen receptor (CAR)-modified T-cells (CAR-T) have demonstrated promising clinical benefits against B-cell malignancies. Yet, its application for solid tumors is still facing challenges. Unlike haematological cancers, solid tumors often lack good targets, which are ideally expressed on the tumor cells, but not by the normal healthy cells.

Modelling noise annoyance responses to combined sound sources and views of sea, road traffic, and mountain greenery.

This paper studies the effect of human perception of visual and audio settings in an urban environment on annoyance. Video clips were projected onto a window panel of a living room to simulate neighborhood views containing different percentages of sea, mountain greenery, and road. These video clips were combined with audio stimuli corresponding to the congruent traffic and sea sounds.