Publications by authors named "Tyrus Vong"
Article Synopsis
- A study at Johns Hopkins Hospital compared outcomes of patients who received neoadjuvant immunotherapy before surgery with those who had upfront resection; 36 of the 92 patients received the immunotherapy.
- The results showed that patients who underwent neoadjuvant immunotherapy had similar resection margins and recurrence-free survival rates compared to those who had upfront surgery, suggesting that this approach might help high-risk patients achieve comparable outcomes.
COVID-19 Diarrhea Is Inflammatory, Caused by Direct Viral Effects Plus Major Role of Virus-induced Cytokines.
Cell Mol Gastroenterol Hepatol
October 2024
Background & Aims: Diarrhea occurs in up to 50% of cases of COVID-19. Nonetheless, the pathophysiologic mechanism(s) have not been determined.
Methods: This was examined using normal human enteroid monolayers exposed apically to live SARS-CoV-2 or non-replicating virus-like particles (VLPs) bearing the 4 SARS-CoV-2 structural proteins or irradiated virus, all of which bound and entered enterocytes.
Background & Aims: The adipokine CTRP3 has anti-inflammatory effects in several nonintestinal disorders. Although serum CTRP3 is reduced in patients with inflammatory bowel disease (IBD), its function in IBD has not been established. Here, we elucidate the function of CTRP3 in intestinal inflammation.
View Article and Find Full Text PDFBackground: Malnutrition has been linked to adverse health economic outcomes. There is a paucity of data on malnutrition in patients admitted with COVID-19. Methods: This is a retrospective cohort study consisting of 4311 COVID-19 adult (18 years and older) inpatients at 5 Johns Hopkins-affiliated hospitals between 1 March and 3 December 2020.
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