Publications by authors named "Tyree Staple"
Article Synopsis
- Ovarian hormones influence the immune system in the female genital tract (FGT), and this study explores how the menstrual cycle affects HIV target cell levels and memory CD4 T cells.
- Researchers collected endocervical cells from 105 healthy women and analyzed different CD4 T cell subsets, focusing on their distribution and function during the follicular and luteal phases of the menstrual cycle.
- Results showed that certain CD4 T cell types were more prevalent in the follicular phase, which may increase susceptibility to HIV, highlighting the dynamic changes in immune response linked to hormonal fluctuations throughout the menstrual cycle.
Background: Gonadal hormones can modify immune function, which may impact susceptibility to infectious diseases, including Human Immunodeficiency Virus (HIV). There is limited knowledge about how hormonal contraceptives (HC) influence the immune response during the course of use. The CHIME study aims to evaluate the effect of long-acting progestin-based hormonal contraceptives (depot medroxyprogesterone acetate, etonogestrel implant, and levonorgestrel intrauterine device) on immunologic changes in the female genital tract (FGT) and systemic compartment.
View Article and Find Full Text PDF