Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon.

Background: Diazinon is one of the most common pesticides in the world playing a similar role to radiation and it could cause DNA breaks and genetic effects.

Objective: In this study, radiosensitivity of a lymphoblastic cell line pretreated by Diazinon was investigated.

Material And Methods: In this case-control study, the human lymphoblastic T-cell line was divided into 6 groups based on receiving radiation or/and Diazinon.

The Consequence of Complete Dentures on Quality of Life of Edentulous Patients in the South-Indian Population Based on Educational and Socioeconomic Grades.

Purpose The purpose of this study was to establish the level of denture satisfaction with socio-demographic variables and educational status of the patients rehabilitated with complete denture. Materials and method A total number of 250 completely edentulous patients were selected who fulfilled the inclusion and exclusion criteria. The patients had no past medical history which affects the oral condition; they were first-time denture wearers with period of edentulousness altering between six months to one year and were in the age group of 40-50 years, and were willingly involved in the study.

Pyrimidine Derivative Schiff Base Ligand Stabilized Copper and Nickel Nanoparticles by Two Step Phase Transfer Method; in Vitro Anticancer, Antioxidant, Anti-Microbial and DNA Interactions.

Pyrimidine derivative Schiff base ligand (DPMC) stabilized metal nanoparticles of copper (DPMC-CuNPs) and nickel (DPMC-NiNPs) were synthesized by modified Brust-Schiffrin technique, which is a two-step phase transfer assisted synthesis. The prepared metal nanoparticles were confirmed by UV-Visible and Infrared spectroscopy. The size, surface morphology and the quality of the DPMC and its MNPs were analyzed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) methods respectively.

A novel method of motor imagery classification using eeg signal.

A subject of extensive research interest in the Brain Computer Interfaces (BCIs) niche is motor imagery (MI), where users imagine limb movements to control the system. This interest is owed to the immense potential for its applicability in gaming, neuro-prosthetics and neuro-rehabilitation, where the user's thoughts of imagined movements need to be decoded. Electroencephalography (EEG) equipment is commonly used for keeping track of cerebrum movement in BCI systems.

A competent bidrug loaded water soluble chitosan derivative for the effective inhibition of breast cancer.

Drug resistance and damage caused to the normal cells are the drawbacks which have limited the use of the existing effective anticancer drugs. Attainment of a steady and extended release by encapsulating dual drugs into biocompatible and biodegradable vehicles is the key to enable the use of these drugs for effective inhibition of cancer. In this study, carboxymethyl chitosan (CMCS), a proficient water-soluble derivative of chitosan has been synthesized using chemical route and used for the delivery of 5-Fluorouracil and doxorubicin individually as well as in combination.

High-throughput method for Antibiotic Susceptibility Testing based on Fluorescein Quenching by Bacteria: Application to Urinary Tract Infection.

We recently reported a sugar-induced bacterial release of 13-Docosenamide and its ability to quench fluorescein. This simple handle to monitor bacterial growth is readily applicable to develop a quicker antibiotic sensitivity testing method along with a low-cost field-use optical instrumentation. Conditions were standardized to perform this new procedure in the most preferred and CLSI-recommended microdilution format in 12-well strips.

PREVALENCE AND CLINICAL FORMS OF MALARIA AMONG FEBRILE HIV-INFECTED CHILDREN SEEN AT USMANU DANFODIYO UNIVERSITY TEACHING HOSPITAL, SOKOTO, NIGERIA.

Background: Malaria and HIV infections are major health problems facing the world today. Sub-Saharan Africa with 10 percent of world's population harbors more than half the burden of the scourge. The present study determined the prevalence and clinical forms of malaria among febrile HIV-infected children aged 3months to 15years, seen in Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, Nigeria.

A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product.

A stability-indicating high-performance liquid chromatography method for Pemetrexed bulk was developed and validated as per the ICH guidelines by employing design of experiments methodology equipped with Box-Behnken design. The separation of Pemetrexed and its oxidative degradation product was achieved in isocratic elution mode with Zorbax C column (150 mm x 4.6 mm x5 μm) using 10 mM ammonium acetate (pH 4.

Coronary Artery Calcium Score as a Predictor of Cardiovascular Risk in Asymptomatic Patients of Type 2 Diabetes.

Introduction: Diabetes mellitus has assumed the status of an epidemic in the last century. High prevalence of diabetes in South Asian population and presence of other cardiovascular risk factors in this region, make up the relationship between coronary artery disease (CAD) and diabetes more pronounced. Keeping in view the high susceptibility of diabetic patients for CAD, these patients are recognized as a high risk group .

Residential exposure to radon and levels of histone γH2AX and DNA damage in peripheral blood lymphocytes of residents of Kowary city regions (Poland).

Introduction: Radon-induced biological effects have been studied mainly through epidemiological investigations, and well-controlled in vitro and in vivo experiments. To provide data explaining radon exposure-induced harmful effects in natural environment, exposure assessment under these conditions is needed. The objective of the study was to examine the level of genetic damage assessed with biomarkers of DNA single- and double-strand breaks (SSBs and DSBs) in peripheral blood mononuclear cells obtained from individuals continuously exposed to Rn in homes.

An efficient single pot DNA recombination method for protein library generation.

A simple single pot method was developed to generate a library of protein hybrids/chimeras from unrelated parents. This method allows unbiased facile DNA shuffling based recombination between the parents with the introduction of type IIB restriction enzyme, BsaXI, at multiple distinct crossover sites. To assess this methodology, B1 immunoglobulin domain of protein G and top7 were recombined at four sites, yielding 2 (32) possible hybrid proteins.

Anthraquinone from Edible Fungi Pleurotus ostreatus Protects Human SH-SY5Y Neuroblastoma Cells Against 6-Hydroxydopamine-Induced Cell Death-Preclinical Validation of Gene Knockout Possibilities of PARK7, PINK1, and SNCA1 Using CRISPR SpCas9.

Parkinson's disease (PD) results from the degeneration of the nervous tissue brought about by ecological and hereditary components which affects nerve cells in the brain. It is the world's second most normal neurodegenerative issue, which can essentially weaken the personal satisfaction, make reliance, and trigger untimely mortality of affected people. The commonness pace of PD is 0.

Integrated approach for data acquisition, visualization and processing of analog polarographic systems for bioenergetics studies.

Bioenergetic function is characterized with assays obtained by polarographic systems. Analog systems without data acquisition, visualization, and processing tools are used but require cumbersome operations to derive respiration rate and ADP to oxygen stoichiometry of oxidative phosphorylation (ADP/O ratio). The analog signal of a polarograhic system (YSI-5300) was digitized and a graphical user interface (GUI) was developed in MATLAB to integrate visualization, recording, calibration and processing of bioenergetic data.

Fat embolism syndrome: Experience from an Australian trauma centre.

Background: Fat Embolism Syndrome (FES) is a rare condition where circulating fat emboli can lead to life threatening multisystem dysfunction. Diagnosis of FES occurs mainly by exclusion. The aim of this study was to describe the injury, event details, and factors associated with the diagnosis of FES following trauma presenting to a Level 1 Trauma Centre in Melbourne, Australia.

A Novel Computer-Aided Method to Evaluate Scoliosis Curvature using Polynomial Math Function.

Background: Scoliosis is a health problem that causes a side-to-side curvature in the spine. The curvature may have an "S" or "C" shape. To evaluate scoliosis, the Cobb angle has been commonly used.

Maternal and neonatal outcomes of cancer during pregnancy: a multi-center observational study.

Cancer during pregnancy has increased because of the increased maternal age at the time of the first pregnancy and/or second child policy in China. The main purpose of the study is to report the existing data concerning the maternal and children's outcomes in pregnant women complicating cancer. In this multi-center, prospective cohort study, we compared women diagnosed with cancer during pregnancy and their children with matched women without cancer diagnoses.

BF VHDR based dynamic routing with hydrodynamics for QoS development in WSN.

The Hydrodynamic characteristics has been considered for routing in Wireless Sensor Networks by various researchers and presented several methods. The flow and friction based routing approaches would produces sustainable results but would not improve the QoS. To improve the performance of FVHDR (Flow -Flow-Friction-Velocity Based Hydro Dynamic Routing), this paper present BFVHDR (Back Flow -Flow-Friction-Velocity Based Hydro Dynamic Routing) algorithm.

Secondary homonymy in Bryozoa: the case of Reteporella jullieni (Cheilostomatida).

The name Reteporella jullieni is currently used to designate two different species of bryozoans from Atlantic deep waters, Reteporella jullieni (Calvet, 1907), described originally as Retepora arborea from the northwest of Spain, and Reteporella jullieni Calvet, 1931, described from the Azores. Successive changes in the genus assignation of the first species, until its current inclusion in the genus Reteporella, have caused the present situation. This represents a case of secondary homonymy as described in the International Code of Zoological Nomenclature.

Evolutionary approaches in protein engineering towards biomaterial construction.

The tailoring of proteins for specific applications by evolutionary methods is a highly active area of research. Rational design and directed evolution are the two main strategies to reengineer proteins or create chimeric structures. Rational engineering is often limited by insufficient knowledge about proteins' structure-function relationships; directed evolution overcomes this restriction but poses challenges in the screening of candidates.

Role of Diagnostic Splenectomy in Patients Presenting with Pyrexia of Unknown Origin with Splenomegaly and Non-Contributory Pre-surgical Evaluation.

Aims: To describe the clinical and laboratory profile, post-surgical complications and longitudinal outcomes in a historical cohort of pyrexia of unknown origin (PUO) patients with splenomegaly who underwent a diagnostic splenectomy following non-contributory extensive pre-surgical laboratory and radiological evaluation.

Materials And Methods: This retrospective study was conducted in a 2700 bed teaching hospital in South India, in eligible patients, over a 10-year period.

Results: Out of 38 PUO patients who underwent diagnostic splenectomy, a final diagnosis was established in 30 patients.

A case report of pulmonary embolism during electroconvulsive therapy and its further application after somatic stabilization.

We describe a case of a 49-year-old, male, Caucasian, pharmaco-resistant patient with a recurrent major depressive disorder, who developed acute pulmonary embolism during a course of inpatient right-unilateral ultra-brief electroconvulsive therapy. After the stabilization of his somatic condition, we were able to safely continue with further ECT applications until his mood normalized and he was able to return to his normal life outside the hospital. Case reports on this topic are scarce - our article demonstrates that electroconvulsive treatment, with proper precautionary measures (anti-aggregative or anti-coagulation prophylaxis) is safe and can be administered without unnecessary delay.

A Glance at the Errors of Some Studies on the Health Effects of High Background Natural Radiation Areas.

There is no place on the Earth, the planet we live on, where the natural background radiation level is zero. Since the birth and even in our fetal stage, we have been exposed to different sources of natural radiation. Life, in fact, evolved in a radiation environment that was much more harsh than today.

Computational Approach To Reveal the Structural Stability and Electronic Properties of Lithiated M/CNT (M = Si, Ge) Nanocomposites as Anodes for Lithium-Ion Batteries.

This work is motivated to explore the structural stability and electronic and electrochemical properties of nanocomposites of MLi (M = Si and Ge)-carbon nanotube (CNT) by employing first-principles density functional theory calculations. By analyzing the structural stability of various MLi ( = 0-10) clusters, it is revealed that a tetrahedron-shaped MLi Zintl cluster is found to be highly stable. Our study on the interaction between the lithiated clusters and CNT illustrates that the charge transfer from the former to latter plays a pivotal role in stabilizing these nanocomposites.