Heparin-protamine mismatch. A controllable factor in bleeding after open heart surgery.

Objective: To test the effect of a new system designed to reduce heparin-protamine mismatch on bleeding after open heart surgery.

Design: Nonrandomized but consecutive retrospective review of patients undergoing open heart surgery during a 9-month period.

Setting: Multispecialty referral center.

Experimentally induced intermittent sinusoidal heart rate pattern and sleep cycle in fetal lambs.

Objective: Intermittent sinusoidal heart rate pattern, an early indicator of fetal anemia, has been speculated to have a positive correlation with fetal sleep cycles. To test this hypothesis, intermittent sinusoidal heart rate patterns were produced experimentally with arginine vasopressin in six methylatropinized fetal lambs that were demonstrating clear rapid-eye-movement and non-rapid-eye-movement sleep cycling.

Study Design: Eleven trials of arginine vasopressin infusion (40 to 160 mIU per body per minute) were performed on each of six chronically instrumented fetal lambs subsequent to parasympathetic blocking doses of methylatropine (300 to 400 micrograms).

The social construction of gendered migration from the Philippines.

"This article examines how the social construction of gender influences the migration of Filipina overseas workers and contributes to the increased vulnerability and exploitation of women migrants. In particular, direct and indirect socialization processes, as well as gendered and racial stereotypes, are manifest within the labor recruitment process, helping to channel women migrants into the domestic services and entertainment sectors..

Intermittent sinusoidal heart rate pattern in vagotomized fetal lambs.

Objectives: Our aims were to investigate the relationship between the dose of arginine vasopressin and the pattern and duration of arginine vasopressin-induced sinusoidal fetal heart rate and to elucidate the correlation between intermittent sinusoidal heart rate and fetal sleep cycle.

Study Design: Sinusoidal heart rate pattern was induced by intravenous arginine vasopressin infusion at doses from 2 to 78 mlU/min into 11 chronically instrumented fetal lambs with bilateral cervical vagotomy. Appearance and frequency of sinusoidal heart rate, intermittent sinusoidal heart rate, and persistent sinusoidal heart rate were observed along with fetal tracheal pressure and electrooculogram.

Physiologic baroreceptor activity in the fetal lamb.

Objective: We investigated the influences of gestational age and behavioral state on fetal baroreceptor activity.

Study Design: Two protocols were used to analyze low-voltage fast activity and high-voltage slow activity in eight chronically instrumented ovine fetuses at days 127 to 142. In protocol 1 correction of fetal heart rate to mean arterial blood pressure was assessed under physiologic conditions, and the linear regression slope of fetal heart rate on mean arterial pressure was calculated.

Autonomic nervous system regulation of baseline heart rate in the fetal lamb.

Objective: We examined 29 chronically instrumented fetal lambs from 125 to 143 days' gestation to investigate the effects of fetal behavioral states and autonomic nervous system maturation on baseline fetal heart rate.

Study Design: Behavioral states were defined from electrocorticographic analysis as low-voltage fast activity or high-voltage slow activity. Decrease and increase in baseline fetal heart rate subsequent to administration of propranolol and methylatropine represented beta-sympathetic and parasympathetic activity.

Cardiovascular responses to norepinephrine and arginine vasopressin infusion in chronically catheterized fetal lambs.

Fetal cardiovascular responses to infused norepinephrine (NE) and arginine vasopressin (AVP) were compared in bilaterally vagotomized and chronically catheterized (control) fetal lambs. In the control fetuses, NE infusion was characterized during the first five minutes by a decreased fetal heart rate (FHR) and increased mean arterial blood pressure (MABP) and by a preejection period (PEP) followed by a gradual return to the original values. NE infusion in vagotomized fetuses was followed by tachycardia, decreased PEP without the initial prolongation and an MABP response similar to that in the controls.

Discrimination of hepatitis B virus (HBV) subtypes using monoclonal antibodies to the PreS1 and PreS2 domains of the viral envelope.

We report the production and characterization of murine anti-PreS2 and anti-PreS1 monoclonal antibodies (mAb) and demonstrate their utility in discriminating hepatitis B virus (HBV) subtypes. On the basis of Western blotting and reciprocal competition binding to HBV virions, at least five distinct epitopes have been identified in the PreS domain: two within the PreS1 region and three within the PreS2 region. All PreS2 mAb bind M protein (gp33 and gp36) but only one group binds strongly to M and L proteins (p39 and gp42).

Effects of norepinephrine on lung fluid flow rate in the chronically catheterized fetal lamb.

The influence of norepinephrine on lung fluid flow rate was studied in seven chronically catheterized fetal lambs. Lung fluid was collected through a catheter inserted into the fetal trachea. In six experiments, continuous saline solution infusion for 1 hour followed by equivolumnar norepinephrine (3.

Postperfusion coronary stenosis.

A patient is described who had left main coronary artery stenosis four months after aortic valve replacement. He was seen with unstable angina, and subsequent catheterization revealed stenosis of a previously normal left main coronary artery. The diagnosis, treatment, and means of prevention are discussed.

Effect of arginine vasopressin on arterial oxygen partial pressure in the chronically catheterized fetal lamb.

Fetal plasma 2,3-Diphosphoglycerate (2,3-DPG) and glucose levels were observed during infusion of arginine vasopressin into 6 chronically catheterized fetal lambs. Low dose infusion of arginine vasopressin (5-10 mIU/min.) did not change fetal arterial blood gases significantly.

Experimentally produced sinusoidal fetal heart rate pattern in the chronically instrumented fetal lamb.

A sinusoidal fetal heart rate and elevated fetal arginine vasopressin levels were found in two bled fetal lambs. Arginine vasopressin was continuously infused intravenously in chronically instrumented fetal lambs at rates ranging between 1.0 and 90 mlU/kg/min.

Follicular fluid effects on progesterone secretion are not due to follicle-stimulating hormone or steroids.

An antiserum raised against porcine follicle-stimulating hormone (FSH) was unable to eliminate the stimulatory action of fluid from large antral porcine follicles on progesterone secretion by granulosa cells from small antral porcine follicles. The same titers of the antiserum were completely effective at eliminating the effect of 2 micrograms of NIH-FSH-P12, whereas maximal stimulation of progesterone secretion was observed with 0.5 micrograms FSH/ml.

Action of histamine and its receptor blockers on uterine circulation in sheep.

Effects of iv and ia administration of histamine and its H1 and H2 blockers (diphenhydramine and metiamide) on systemic arterial pressure, heart rate, and uterine and iliac blood flows were investigated in unanesthetized, chronically instrumented nonpregnant ewes. Intravenous histamine produced tachycardia, hypotension, and decreased iliac and uterine blood flows. In contrast, ia injections produced a significant increase in blood flows in these vascular beds which was dose-dependent.