Robust Optimal Design of Energy Efficient Series Elastic Actuators: Application to a Powered Prosthetic Ankle.

Design of rehabilitation and physical assistance robots that work safely and efficiently despite uncertain operational conditions remains an important challenge. Current methods for the design of energy efficient series elastic actuators use an optimization formulation that typically assumes known operational requirements. This approach could lead to actuators that cannot satisfy elongation, speed, or torque requirements when the operation deviates from nominal conditions.

Maternal high-fat diet results in cognitive impairment and hippocampal gene expression changes in rat offspring.

Consumption of a high-fat diet has long been known to increase risk for obesity, diabetes, and the metabolic syndrome. Further evidence strongly suggests that these same metabolic disorders are associated with an increased risk of cognitive impairment later in life. Now faced with an expanding global burden of obesity and increasing prevalence of dementia due to an aging population, understanding the effects of high-fat diet consumption on cognition is of increasingly critical importance.