Publications by authors named "Tyler Stahl"
Background: While platelets have well-studied hemostatic functions, platelets are immune cells that circulate at the interface between the vascular wall and white blood cells. The physiological implications of these constant transient interactions are poorly understood. Activated platelets induce and amplify immune responses, but platelets may also maintain immune homeostasis in healthy conditions, including maintaining vascular integrity and T helper cell differentiation, meaning that platelets are central to both immune responses and immune quiescence.
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- Platelets function as immune cells in addition to their role in blood clotting, directly influencing immune responses and vascular health through interactions with leukocytes.
- Thrombocytopenia, or low platelet counts, disrupts this balance and leads to monocyte dysfunction, causing increased immune responses which may lead to inflammation.
- Research shows that normal platelet levels are crucial for maintaining immune homeostasis, as they regulate the immunometabolic processes in monocytes, leading to epigenetic changes that affect immune gene expression.
: To understand Parkinson's Disease (PD) care partners' a) challenges that led to worsening strain and b) their suggestions for supports to help them during the ongoing pandemic. : Using a qualitative descriptive design, semi-structured interviews with family care partners (n 19) were completed. Participants were recruited from 10 sites across the United States that varied in size, demographics of patient population served, and geographic location (urban, suburban, rural).
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- The study focused on comparing mRNA expression changes between identical twins, one of whom sustained a sports-related concussion (SRC), to identify recovery-related gene expression.
- Significant transcriptional changes, particularly involving the ErbB signaling pathway, were found in 153 genes post-injury compared to pre-injury levels.
- This research suggests that co-twin studies can effectively reveal key genetic pathways that may influence recovery from concussion.
Controlling acidic degradation of biodegradable polyesters remains a major clinical challenge. This work presents a simple and effective strategy of developing polyester composites with biodegradable magnesium metal or alloys. PLGA samples with compositions of 1, 3, 5, and 10 wt% magnesium were produced using a simple solvent-casting method, which resulted in composite films with near uniform Mg metal/alloy particle dispersion.
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