Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta-analysis.

Background: Cholinesterase inhibitors (ChEIs) are regularly used in Alzheimer's disease. Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million prescriptions in 2020; however, it is classified as a "known risk" QT interval-prolonging medication (QTPmed). Given this claim is derived from observational data including single case reports, we aimed to evaluate high-quality literature on the frequency and nature of proarrhythmic major adverse cardiac events (MACE) associated with donepezil.

Hydroxychloroquine-Chloroquine, QT-Prolongation, and Major Adverse Cardiac Events: A Meta-analysis and Scoping Review.

Objectives: We aimed to evaluate the high-quality literature on the frequency and nature of major adverse cardiac events (MACE) associated with either hydroxychloroquine (HCQ) or chloroquine (CQ).

Data Sources: We searched Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Central from 1996 onward using search strategies created in collaboration with medical science librarians.

Study Selection And Data Extraction: Randomized controlled trials (RCTs) published in English language from January 1996 to September 2022, involving adult patients at least 18 years of age, were selected.

Comparisons of Insulin Spending and Price Between Canada and the United States.

Insulin prices have been a hot topic in the United States, where there is a lack of price regulation on drugs, and there have been reports of Americans crossing the border to purchase insulin in Canada at much lower prices. We conducted a cross-sectional time-series analysis comparing insulin spending using IQVIA (Durham, North Carolina, USA) data on aggregate insulin prescription volumes dispensed in the United States and Canada from January 2016 to April 2019 to quantify insulin spending and pricing differences between the countries. We obtained data on diabetes rates from the US Centers for Disease Control and Prevention and Statistics Canada.