Internet-enabled lab-on-a-chip technology for education.

Despite many interventions, science education remains highly inequitable throughout the world. Internet-enabled experimental learning has the potential to reach underserved communities and increase the diversity of the scientific workforce. Here, we demonstrate the use of lab-on-a-chip (LoC) technologies to expose Latinx life science undergraduate students to introductory concepts of computer programming by taking advantage of open-loop cloud-integrated LoCs.

Dual optofluidic distributed feedback dye lasers for multiplexed biosensing applications.

Integrated optofluidic devices have become subjects of high interest for rapid biosensor devices due to their unique ability to combine the fluidic processing of small volumes of microfluidics with the analysis capabilities of photonic structures. By integrating dynamically reconfigurable optofluidic lasers on-chip, complex coupling can be eliminated while further increasing the capabilities of sensors to detect an increasing number of target biomarkers. Here, we report a polydimethylsiloxane-based device with two on-chip fluidic distributed feedback (DFB) laser cavities that are integrated with an orthogonal analyte channel for multiplexed fluorescence excitation.

Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students.

Despite many interventions, science education remains highly inequitable throughout the world. Among all life sciences fields, Bioinformatics and Computational Biology suffer from the strongest underrepresentation of racial and gender minorities. Internet-enabled project-based learning (PBL) has the potential to reach underserved communities and increase the diversity of the scientific workforce.

All-in-One Optofluidic Chip for Molecular Biosensing Assays.

Integrated biosensor platforms have become subjects of high interest for consolidated assay preparation and analysis to reduce sample-to-answer response times. By compactly combining as many biosensor processes and functions as possible into a single lab-on-chip device, all-in-one point-of-care devices can aid in the accessibility and speed of deployment due to their compact size and portability. Biomarker assay preparation and sensing are functionalities that are often carried out on separate devices, thus increasing opportunity of contamination, loss of sample volume, and other forms of error.

Pneumatically tunable optofluidic DFB dye laser using corrugated sidewalls.

Polydimethylsiloxane-based optofluidics provides a powerful platform for a complete analytical lab-on-chip. Here, we report on a novel on-chip laser source that can be integrated with sample preparation and analysis functions. A corrugated sidewall structure is integrated into a microfluidic channel to form a distributed feedback (DFB) laser using rhodamine 6G dissolved in an ethylene glycol and water solution.

Two-dimensional combination of eight ultrashort pulsed beams using a diffractive optic pair.

We demonstrate, to the best of our knowledge, the first two-dimensional diffractive beam combination for ultrashort pulses-a highly scalable technique capable of using a diffractive optic pair to combine large arrays of ultrashort pulsed beams. A square array of eight 120 fs pulsed beams from eight fiber outputs is coherently combined into one beam using the diffractive combiner. The experimental results show that the combined pulse preserves the input pulse width and shape, and the combining efficiency is measured to be close to the limit of the manufactured diffractive optic.

Coherent combination of ultrashort pulse beams using two diffractive optics.

A novel coherent beam combiner, capable of combining large numbers of femtosecond pulse beams using two diffractive optics, is presented. The diffractive optic pair cancels pulse front tilt, while uncorrected dispersions are minimized. An example using four beams is modeled numerically and tested experimentally, demonstrating 120 fs pulses combined without degradation of pulse width.