Risk factors, management, and outcomes of keratitis: A retrospective analysis of 110 cases.

Purpose: To evaluate the risk factors, medical and surgical management, and visual outcomes of patients affected by keratitis (AK) over a 16-year period.

Observations: Records were reviewed retrospectively for all AK patients treated at University of Iowa between 2002 and 2017. Main outcomes measured were risk factors, time to diagnosis, coinfection types, initial and final visual acuities, and treatment outcomes, with failure of medical therapy defined as need for therapeutic keratoplasty (TK).

Long-Term Follow-Up of Normal Tension Glaucoma Patients With TBK1 Gene Mutations in One Large Pedigree.

Purpose: To characterize features of glaucoma associated with a TANK binding kinase 1 (TBK1) gene duplication, which is among the most common molecularly defined causes of normal tension glaucoma (NTG).

Design: Retrospective observational case series.

Methods: We conducted a retrospective case series, by reviewing medical records of 7 members of a pedigree with NTG caused by TBK1 gene duplications.

Long-term changes in keratometry and refraction after small aperture corneal inlay implantation.

Purpose: To assess longitudinal refractive, keratometric, and topographic changes following KAMRA small-aperture inlay implantation.

Design And Setting: Prospective study at a single site refractive surgery center.

Methods: Fifty patients underwent KAMRA small-aperture corneal inlay implantation for the correction of presbyopia.

Case of Presumed Transient Light-Sensitivity Syndrome After Small-Incision Lenticule Extraction.

Purpose: To report the first presumed case of transient light-sensitivity syndrome (TLSS) after small-incision lenticule extraction (SMILE).

Methods: A 27-year-old male patient was treated for severe photophobic symptoms occurring 7 weeks after undergoing a bilateral SMILE procedure. His comprehensive ocular examination was unremarkable and his visual acuity was unaffected.

Cataract Surgery in Patients with a Previous History of KAMRA Inlay Implantation: A Case Series.

Introduction: The visual outcome of cataract surgery in patients with a previous history of KAMRA inlay implantation is an emerging issue for which limited research exists. The purpose of this study is to describe postoperative visual outcomes in this patient population.

Methods: This is a case series with retrospective chart review.

Stereoacuity after small aperture corneal inlay implantation.

Purpose: The aim of this study was to compare stereoacuity before and after KAMRA corneal inlay implantation for the correction of presbyopia.

Patients And Methods: This is a prospective study of 60 patients who underwent KAMRA inlay implantation. Patients were examined before and 6 months after surgery for stereoacuity, uncorrected distance visual acuity (UDVA), and uncorrected near visual acuity (UNVA).

Rainbow glare after laser-assisted in situ keratomileusis: a review of literature.

This article reviews the current literature pertaining to rainbow glare (RG), including incidence rate, clinical presentation, etiology, prognosis, and management. RG is a rare optical complication of femtosecond laser-assisted in situ keratomileusis that results in patients seeing an array of spectral bands surrounding point sources of light under mesopic and scotopic conditions. The mechanism is thought to be a consequence of the formation of a transmissive diffraction grating on the posterior surface of the corneal flap created by the FS laser.

Six-month visual outcomes for the correction of presbyopia using a small-aperture corneal inlay: single-site experience.

Objective: The objective of this study was to describe 6-month postoperative efficacy and safety outcomes after monocular KAMRA corneal inlay implantation in emmetropic presbyopic patients.

Study Design: This study followed a retrospective chart analysis.

Setting: This study was performed at Hoopes Vision in Draper, UT, USA.

Hearing preservation after middle fossa vestibular schwannoma removal: are the results durable?

Objective: To describe 5-year hearing preservation rates following microsurgical excision of vestibular schwannoma (VS) via the middle cranial fossa (MCF) approach.

Study Design: Case series with chart review.

Setting: This study was performed at a tertiary care academic medical center.

Rapid and efficient zebrafish genotyping using PCR with high-resolution melt analysis.

Zebrafish is a powerful vertebrate model system for studying development, modeling disease, and performing drug screening. Recently a variety of genetic tools have been introduced, including multiple strategies for inducing mutations and generating transgenic lines. However, large-scale screening is limited by traditional genotyping methods, which are time-consuming and labor-intensive.

Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding.

foxP2, a forkhead-domain transcription factor, is critical for speech and language development in humans, but its role in the establishment of CNS connectivity is unclear. While in vitro studies have identified axon guidance molecules as targets of foxP2 regulation, and cell culture assays suggest a role for foxP2 in neurite outgrowth, in vivo studies have been lacking regarding a role for foxP2 in axon pathfinding. We used a modified zinc finger nuclease methodology to generate mutations in the zebrafish foxP2 gene.

Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish.

Dorsal retinal fate is established early in eye development, via expression of spatially restricted dorsal-specific transcription factors in the optic vesicle; yet the events leading to initiation of dorsal fate are not clear. We hypothesized that induction of dorsal fate would require an extraocular signal arising from a neighboring tissue to pattern the prospective dorsal retina, however no such signal has been identified. We used the zebrafish embryo to determine the source, timing, and identity of the dorsal retina-inducing signal.