Predicting high-performance decathlon career best.

The decathlon is a 10-event discipline in the sport of track and field, typically offered only for men at the elite level of competition (heptathlon is the complementary event for women). It is composed of 10 distinct events contested over 2 days. Using event-specific coefficients, marks are converted to scores, which sum to produce an overall score.

Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and Patterns.

The selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well-defined. In this study, we use Cut&Run to examine genomic binding locations for TICRR/TRESLIN and MTBP, the human orthologs for the yeast DNA replication initiation factors Sld3 and Sld7. We mapped TRESLIN and MTBP binding in HCT116 colorectal cancer cells using asynchronous and G1 synchronized populations.

A Narrative Analysis of the Progression in the Top 100 Marathon, Half-Marathon, and 10-km Road Race Times from 2001 to 2019.

Purpose: This study aimed to characterize and describe finishing time trends of the fastest 100 performers in the men's and women's marathon, half-marathon, and road 10-km each year from 2001 to 2019 and assess the underlying basis for recent performance improvements.

Methods: The top 100 performers for each sex, event, and year were partitioned into four arbitrary ranking groups: 1-10, 11-25, 26-50, and 51-100. The percent improvement in mean performance time for each year beyond 2001 was calculated for each ranking group, event, and sex.

The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.

A DNA replication program, which ensures that the genome is accurately and wholly replicated, is established during G1, before the onset of S phase. In G1, replication origins are licensed, and upon S phase entry, a subset of these will form active replisomes. Tight regulation of the number of active replisomes is crucial to prevent replication stress-induced DNA damage.

Incidence of Vacuum Phenomenon Related Intra-articular or Subfascial Gas Found on Computer-Assisted Tomography (CT) Scans of Closed Lower Extremity Fractures.

Objectives: To determine the incidence of vacuum phenomenon related intra-articular or subfascial gas found on computer-assisted tomography (CT) scans of closed lower extremity fractures.

Design: Retrospective Review.

Setting: Level I Trauma Center.

Marathon Specialization in Elites: A Head Start for Africans.

Purpose: To assess differences in event-specific specialization between elite African and non-African male marathon runners based on age, performance, and career length.

Methods: The top 90 African marathoners from 2001 to 2015 were compared with the top 90 non-African marathoners from the same time period across various markers related to specialization age, performance, and career length. Independent t tests were used to identify significant differences (P < .