Publications by authors named "Tyler N Johnson"
Article Synopsis
- The study investigated the effects of the bisphosphonate clodronate disodium (CLO) on bone health in juvenile sheep over 165 days, analyzing factors like bone turnover, density, and microstructure.
- Forty juvenile sheep were divided into four treatment groups, including a control and three that received CLO at different times, while they were exercised regularly and monitored for physical changes.
- Results showed no significant effects of CLO on the sheep's skeleton, with minor changes in serum bone biomarkers attributed to time and exercise, suggesting the need for further research on low-dose bisphosphonates in active juvenile populations.
Background: Pathological fractures have been reported in equids with pituitary pars intermedia dysfunction (PPID) but their prevalence and pathogenesis is unknown.
Objectives: To compare: (1) bone mineral density (BMD) in weight bearing and nonweight bearing bones in PPID equids and aged and young PPID controls; and (2) biomechanical properties of the fourth lumbar vertebral body in PPID equids and aged PPID equids.
Study Design: Case-control study: five PPID equids and six aged and four young PPID control horses.