Publications by authors named "Tyler M Foley"
Background: Mechanical ventilation is a common life-saving procedure but can lead to serious complications, including ARDS and oxygen toxicity. Nonadherence to lung-protective ventilation guidelines is common. We hypothesized that a respiratory therapist-driven mechanical ventilation bundle could increase adherence to lung-protective ventilation and decrease the incidence of pulmonary complications in the ICU.
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- - The study aimed to evaluate endotracheal intubation methods in emergency departments during the early COVID-19 pandemic by analyzing data from 20 US hospitals between May and December 2020.
- - Out of 3,435 intubations performed, 565 patients (18%) were known or suspected to have COVID-19; these patients were more likely to be intubated using video laryngoscopy and passive nasal oxygenation.
- - Although the success rate for the initial intubation attempt was similar between COVID-19 and non-COVID-19 patients, those with known or suspected COVID-19 experienced more adverse events, particularly hypoxia.
mutations are common in clinical molecular profiling, yet an effective means to target these cancers has yet to be developed. MTORC1 inhibitors are often used off-label for patients with mutant cancers with only limited data to support this approach. Here we describe a cohort of patients treated with cancers possessing mutations activating the PI3K signaling cascade with minimal benefit to treatment with the MTORC1 inhibitor everolimus.
View Article and Find Full Text PDFTherapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would benefit from targeting this pathway has yet to be identified.
View Article and Find Full Text PDFThe phosphoinositide 3-kinase (PI3K) signaling pathway is critical for multiple important cellular functions, and is one of the most commonly altered pathways in human cancers. We previously developed a mouse model in which colon cancers were initiated by a dominant active PI3K p110-p85 fusion protein. In that model, well-differentiated mucinous adenocarcinomas developed within the colon and initiated through a non-canonical mechanism that is not dependent on WNT signaling.
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