Publications by authors named "Tyler Lowe"
Standardization of flow cytometric detection of antigen expression.
Cytometry B Clin Cytom
January 2024
Since response to antigen-based immunotherapy relies upon the level of tumor antigen expression we developed an antigen quantification assay using ABC values. Antigen quantification as a clinical assay requires methods for quality control and for interlaboratory and inter-cytometer platform standardization. A single lot of Cytotrol™ Lyophilized Control Cells (Beckman Coulter) used for all studies.
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- Multiple myeloma (MM) is a challenging cancer of plasma cells, and researchers developed a new treatment using a human anti-BCMA CAR called FHVH33-CD8BBZ to target it.
- In a clinical trial involving 25 patients with relapsed MM, the treatment resulted in a 52% stringent complete response rate and a median progression-free survival of 78 weeks.
- While some patients experienced cytokine-release syndrome, it was manageable and most anti-MM effects were observed within 2-4 weeks post-infusion, indicating the treatment's rapid and effective action against the disease.