Publications by authors named "Tyler J Schubert"
Recent guidance by the United States Preventive Services Task Force has renewed the debate surrounding the benefits of pediatric lipid screening. This commentary reviews the evolution of the pediatric lipid screening recommendations in the United States, followed by an exploration of real and imagined challenges that prevent optimal cholesterol screening rates in children. Real challenges substantively prevent the uptake of these guidelines into practice; imagined challenges, such as identifying the best age to screen, are often context-dependent and can also be surmounted.
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- - The CARE-FH clinical trial aimed to enhance screening for Familial Hypercholesterolemia (FH) in primary care settings by incorporating feedback from healthcare professionals involved in patient care.
- - The trial identified that FH screening was infrequent, often occurring only post-cardiovascular events, but found that healthcare providers were generally open to implementing screening with some adjustments.
- - Barriers like limited time during patient visits and lack of knowledge were noted, but effective guidance and new treatments showed promise as facilitators for improving FH screening and care initiation.
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the United States. Case-based learning using electronic delivery of the modules can educate clinicians and improve translation of evidence-based guidelines into practice for high-risk ASCVD patients.
Objective: To develop and optimize module design, content, and usability of e-learning modules to teach clinicians evidence-based management in accordance with multi-society guidelines for high-risk ASCVD patients that will be implemented and evaluated in U.
Purpose Of Review: To review recent international and domestic definitions, considerations, and treatment algorithms for statin intolerance, and specifically, statin-associated muscle symptoms (SAMS).
Recent Findings: Multiple organizations around the world have produced guidance documents to aid clinicians on managing statin intolerance. A common theme resides among all the guidance documents that most patients can tolerate statins.
Article Synopsis
- Telehealth services have grown significantly during the COVID-19 pandemic, particularly for managing chronic conditions like lipid issues, yet their precise impact on lipid management practices is not well understood.
- A research review identified 55 relevant articles, primarily randomized trials, showing that telehealth generally had positive to neutral effects on lipid management, supported by easier care integration and patient-centered approaches.
- Barriers to effective telehealth include technological issues, costs, patient adherence challenges, and inconsistencies in clinician practices, highlighting the need for more research to assess the long-term viability of telehealth for lipid management.
Article Synopsis
- - The CARE-FH study at Geisinger aims to enhance the identification of Familial Hypercholesterolemia (FH) by integrating diagnostic evaluations into primary care settings, focusing on early detection before cardiovascular diseases develop.
- - The study employs implementation science to develop and apply strategies based on evidence-based guidelines, ensuring clinicians are well-equipped to diagnose FH effectively.
- - The project is conducted in two phases: the first focuses on designing the trial and developing strategies, while the second assesses the rollout of the intervention across various medical fields and evaluates its impact on diagnostic rates and health outcomes.
The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), thyroglobulin, connexin 43 hemichannels, and proinsulin. ERp29 is hypothesized to promote ER to Golgi cargo protein transport COP II machinery through its interactions with the KDEL receptor; this interaction may facilitate the loading of ERp29 clients into COP II vesicles.
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