The Impact of Natural Environments and Biophilic Design as Supportive and Nurturing Spaces on a Residential College Campus.

With so many college students experiencing disengagement, the physical design of a college and the connection to its natural surroundings has the potential for profound change. Natural environments, even viewing pictures of them, have the potential to positively impact parasympathetic nervous systems, increase cognitive functioning, and improve attention. This study investigated college student perceptions of their personal well-being with attention to coping, self-esteem, and physical health in a residential academic setting in the northeastern United States.

Plenty of Room at the Top: A Multi-Scale Understanding of nm-Resolution Polymer Patterning on 2D Materials.

Lamellar phases of alkyldiacetylenes in which the alkyl chains lie parallel to the substrate represent a straightforward means for scalable 1-nm-resolution interfacial patterning. This capability has the potential for substantial impacts in nanoscale electronics, energy conversion, and biomaterials design. Polymerization is required to set the 1-nm functional patterns embedded in the monolayer, making it important to understand structure-function relationships for these on-surface reactions.

Replay in Deep Learning: Current Approaches and Missing Biological Elements.

Replay is the reactivation of one or more neural patterns that are similar to the activation patterns experienced during past waking experiences. Replay was first observed in biological neural networks during sleep, and it is now thought to play a critical role in memory formation, retrieval, and consolidation. Replay-like mechanisms have been incorporated in deep artificial neural networks that learn over time to avoid catastrophic forgetting of previous knowledge.

Oleylamine Impurities Regulate Temperature-Dependent Hierarchical Assembly of Ultranarrow Gold Nanowires on Biotemplated Interfaces.

Nanocrystals are often synthesized using technical grade reagents such as oleylamine (OLAm), which contains a blend of octadeceneamine with -unsaturated and saturated amines. Here, we show that gold nanowires (AuNWs) synthesized with OLAm ligands undergo thermal transitions in interfacial assembly (ribbon . nematic); transition temperatures vary widely with the batch of OLAm used for synthesis.

Are open set classification methods effective on large-scale datasets?

Supervised classification methods often assume the train and test data distributions are the same and that all classes in the test set are present in the training set. However, deployed classifiers often require the ability to recognize inputs from outside the training set as unknowns. This problem has been studied under multiple paradigms including out-of-distribution detection and open set recognition.

Large-Scale Noncovalent Functionalization of 2D Materials through Thermally Controlled Rotary Langmuir-Schaefer Conversion.

As two-dimensional (2D) materials are more broadly utilized as components of hybrid materials, controlling their surface chemistry over large areas through noncovalent functionalization becomes increasingly important. Here, we demonstrate a thermally controlled rotary transfer stage that allows areas of a 2D material to be continuously cycled into contact with a Langmuir film. This approach enables functionalization of large areas of the 2D material and simultaneously improves long-range ordering, achieving ordered domain areas up to nearly 10 000 μm.

Hierarchically patterned striped phases of polymerized lipids: toward controlled carbohydrate presentation at interfaces.

Complex biomolecules, including carbohydrates, frequently have molecular surface footprints larger than those in broadly utilized standing phase alkanethiol self-assembled monolayers, yet would benefit from structured orientation and clustering interactions promoted by ordered monolayer lattices. Striped phase monolayers, in which alkyl chains extend across the substrate, have larger, more complex lattices: nm-wide stripes of headgroups with 0.5 or 1 nm lateral periodicity along the row, separated by wider (∼5 nm) stripes of exposed alkyl chains.

Spatially Controlled Noncovalent Functionalization of 2D Materials Based on Molecular Architecture.

Polymerizable amphiphiles can be assembled into lying-down phases on 2D materials such as graphite and graphene to create chemically orthogonal surface patterns at 5-10 nm scales, locally modulating functionality of the 2D basal plane. Functionalization can be carried out through Langmuir-Schaefer conversion, in which a subset of molecules is transferred out of a standing phase film on water onto the 2D substrate. Here, we leverage differences in molecular structure to spatially control transfer at both nanoscopic and microscopic scales.

Multimicrometer Noncovalent Monolayer Domains on Layered Materials through Thermally Controlled Langmuir-Schaefer Conversion for Noncovalent 2D Functionalization.

As functionalized 2D materials are incorporated into hybrid materials, ensuring large-area structural control in noncovalently adsorbed films becomes increasingly important. Noncovalent functionalization avoids disrupting electronic structure in 2D materials; however, relatively weak molecular interactions in such monolayers typically reduce stability toward solution processing and other common material handling conditions. Here, we find that controlling substrate temperature during Langmuir-Schaefer conversion of a standing phase monolayer of diynoic amphiphiles on water to a horizontally oriented monolayer on a 2D substrate routinely produces multimicrometer domains, at least an order of magnitude larger than those typically achieved through drop-casting.

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.

Oral squamous cell carcinoma (OSCC) is genetically highly heterogeneous, which contributes to the challenges of treatment. To create an in vitro model that accurately reflects this heterogeneity, we generated a panel of HPV-negative OSCC cell lines. By whole exome sequencing of the lines and matched patient blood samples, we demonstrate that the mutational spectrum of the lines is representative of primary OSCC in The Cancer Genome Atlas.