Synthesis and crystal structure of sodium (ethane-1,2-di-yl)bis-[(3-meth-oxy-prop-yl)phosphinodi-thiol-ate] octa-hydrate.

The title compound, -poly[[tri-aqua-sodium]-di-μ-aqua-[tri-aqua-sodium]-μ-(ethane-1,2-di-yl)bis-[(3-meth-oxy-prop-yl)phosphinodi-thiol-ato]], [Na(CHOPS)(HO)] , crystallizes in the triclinic space group 1. The dianionic [CHO(CH)P(=S)(S-)CHCHP(=S)(S-)(CH)OCH] ligand fragments are joined by a dicationic [Na(HO)] cluster that includes the oxygen of the meth-oxy-propyl unit of the ligand to form infinite chains.

Comprehensive profiling of antibody responses to the human anellome using programmable phage display.

Anelloviruses represent a major constituent of the commensal human virome; however, little is known about their immunobiology. Here, we present "AnelloScan," a T7 phage library representing the open reading frame 1 (ORF1), ORF2, ORF3, and torque teno virus (TTV)-derived apoptosis-inducing protein (TAIP) sequences of more than 800 human anelloviruses and profile the antibody reactivities of serum samples from a cross-sectional cohort of 156 subjects by using phage-immunoprecipitation sequencing (PhIP-Seq). A majority of anellovirus peptides are not reactive in any of the subjects tested (n = ∼28,000; ∼85% of the library).

Solvent Cage Effects: A Comparison of Geminate and Nongeminate Radical Cage Pair Combination Efficiencies.

This study measured and compared the combination efficiencies () of geminate radical cage pairs to nongeminate (collisional) radical cage pairs ('). For the [Cp'(CO)Mo·, ·Mo(CO)Cp'] radical cage pair, ' was found to be smaller than in solutions having the same viscosity. It is proposed that the difference in and ' arises because the radicals in the collisional cage pair are less likely to have the correct orbital orientation for radical-radical combination to occur, whereas photochemically generated geminate cage pairs are more likely to have the correct orbital orientation.

Volar Cortical Integrity in Non-Operatively Treated Adult Distal Radius Fractures.

We sought to independently validate published data that volar cortical integrity (VCI) is an independent predictor of maintenance of closed reduction in a series of non-surgically treated distal radius fractures, while simultaneously investigating previously reported predictors of instability. Our null hypothesis was that volar cortical integrity would not affect maintenance of reduction. Four hundred thirty-three adult distal radius fractures were screened from our Orthopedic database with 112 meeting inclusion criteria.

Validation of the Shin Pain Scoring System: A Novel Approach for Determining Tibial Bone Stress Injuries.

Background: The incidence of adolescent overuse injuries, including bone stress injuries (BSIs), is on the rise. The identification of a BSI in the early stages is key to successful treatment. The Shin Pain Scoring System (SPSS) was developed to aid clinicians in identifying patients with a BSI.

Multi-spectral image shift-estimation error calculations using simulated phenomenology.

Registration of multi-spectral imagery is a critical pre-processing step for applications such as image fusion, but phenomenological differences between spectral bands can lead to significant estimation errors. To develop credible requirements for multi-spectral imaging systems, it is critical to characterize errors, both algorithmic and fundamental, associated with estimating registration parameters; however, attempting to quantify error using archival data sets poses a number of problems. In this paper, we demonstrate the use of commercially available graphics software and available optical property measurements to create fully synthetic, multi-spectral imagery with high-fidelity representations of emissive and reflective phenomenology.

Intrinsic bias in Fisher information calculations for multi-mode image registration.

To address the need for the analysis of image processing and optical requirements in multi-mode imaging systems, such as multi-spectral and polarimetric imagers, I have developed a Fisher information matrix to quantify errors in estimating the shift between images with non-transformational feature differences. If images of the same field have differences not attributable to a geometric transformation, as is common for images acquired using different spectral or polarization filters, uncertainty in estimating the parameters of the transformation will be increased by intrinsic bias, or bias inherent in the data itself, as opposed to bias originating in the estimation algorithm. The approach to shift-estimation error analysis described in this Letter accounts for intrinsic bias, has intuitively expected properties and, given planned system sensitivity and operating conditions, can be used with simulated multi-mode imagery to estimate image registration error and develop realistic requirements.

Airlight-imposed errors for space-object polarimetric observations from the ground.

We discuss and characterize how polarimetric sensing is contaminated by various "airlight" phenomena, as well as unpolarized light from the target, when space objects are observed with a ground-based telescope. Estimates of the polarization state are limited by unpolarized target light regardless of sensor technology or estimator algorithm, and increased target brightness actually degrades estimation of the S, S, and S Stokes parameters if the added light is unpolarized. Unpolarized airlight in the field of view has an identical degrading effect.

Radical Cage Effects: The Prediction of Radical Cage Pair Recombination Efficiencies Using Microviscosity Across a Range of Solvent Types.

This study reports a method for correlating the radical recombination efficiencies (F) of geminate radical cage pairs to the properties of the solvent. Although bulk viscosity (macroviscosity) is typically used to predict or interpret radical recombination efficiencies, the work reported here shows that microviscosity is a much better parameter. The use of microviscosity is valid over a range of different solvent system types, including nonpolar, aromatic, polar, and hydrogen bonding solvents.

AMP: A platform for managing and mining data in the treatment of Autism Spectrum Disorder.

We introduce AMP (Autism Management Platform), an integrated health care information system for capturing, analyzing, and managing data associated with the diagnosis and treatment of Autism Spectrum Disorder in children. AMP's mobile application simplifies the means by which parents, guardians, and clinicians can collect and share multimedia data with one another, facilitating communication and reducing data redundancy, while simplifying retrieval. Additionally, AMP provides an intelligent web interface and analytics platform which allow physicians and specialists to aggregate and mine patient data in real-time, as well as give relevant feedback to automatically learn data filtering preferences over time.

Enhancing Executive Function and Neural Health in Bipolar Disorder through Reasoning Training.

Cognitive deficits in executive function and memory among individuals with bipolar disorder (BD) are well-documented; however, only recently have efforts begun to address whether such cognitive deficits can be ameliorated through cognitive training. This pilot study examined the effects of a top-down, cognitive reasoning training program in adults with BD on both brain and cognitive measures. Twenty-seven participants (11 males, 16 females), aged 21-70 years old, completed the study.

Radical Cage Effects: Comparison of Solvent Bulk Viscosity and Microviscosity in Predicting the Recombination Efficiencies of Radical Cage Pairs.

This study reports the results of experiments that probed how solvents affect the recombination efficiency (FcP) of geminate radical cage pairs. The macroviscosity of solvents has traditionally been used to make quantitative predictions about FcP, but experiments reported here show that FcP varies dramatically for solvent systems with identical macroviscosities. Experiments show that FcP correlates with the solvent microviscosity: five different solvent systems (consisting of a solvent and a structurally similar viscogen) were examined, and FcP was the same for all five solvent systems at any particular microviscosity.

Synthesis of tetraphosphine macrocycles using copper(i) templates.

The synthesis of phosphine macrocycles is a relatively underdeveloped area and no standard synthetic routes have emerged. Accordingly, two general synthetic routes to tetradentate phosphine macrocycles were investigated. Both routes use Cu(i) ions as template ions because, unlike other metals such as Pd(ii) and Pt(ii), the Cu(i) ions can be removed from the macrocyclic complex without degrading the macrocycle ligand.

Steric and Electronic Influences of Buchwald-Type Alkyl-JohnPhos Ligands.

The electron-donating and steric properties of Buchwald-type ligands ([1,1'-biphenyl-2-yl]dialkylphosphine; R-JohnPhos, where R = Me, Et, (i)Pr, Cy, (t)Bu) were determined. The π-acidity and σ-donating properties of the R-JohnPhos ligands were quantified using a Cotton-Kraihanzel analysis of the Cr(0)(CO)5(R-JohnPhos) complexes. Somewhat surprisingly, the σ-donating abilities of the R-JohnPhos ligands follow the trend (t)Bu-JohnPhos < Et-JohnPhos < (i)Pr-JohnPhos < Cy-JohnPhos ≪ Me-JohnPhos.

Cramér-Rao lower bound calculations for image registration using simulated phenomenology.

The Cramér-Rao lower bound (CRLB) is a valuable tool to quantify fundamental limits to estimation problems associated with imaging systems, and has been used previously to study image registration performance bounds. Most existing work, however, assumes constant-variance noise; for many applications, noise is signal-dependent. Further, linear filters applied after detection can potentially yield reduced registration error, but prior work has not treated the CRLB behavior caused by filter-imposed noise correlation.

The synthesis of heteroleptic phosphines.

Heteroleptic phosphines (R2PR(1)) are a class of essential ligands for inorganic and organometallic chemistry. However, the syntheses of these phosphines are often fraught with laborious synthetic hurdles. Consequently, a renewed interest in innovative synthetic methods to access heteroleptic phosphines is emerging.

Crystal structure of trans-dihydrido-bis[tris-(di-methyl-amino)-phosphane-κP]platinum(II).

The mol-ecule of the title compound, [PtH2(C6H18N3P)2], has a centrosymmetric square-planar structure in which the Pt(II) atom is bonded to two H and two P atoms in a mutually trans configuration. The Pt(II) atom sits on an inversion center and thus the asymmetric unit contains only half the mol-ecule. The Pt-P and Pt-H distances are 2.

Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS.

The Drosophila Bithorax complex (BX-C) Hox cluster contains a bidirectionally transcribed miRNA locus, and a deletion mutant (Δmir) lays no eggs and is completely sterile. We show these miRNAs are expressed and active in distinct spatial registers along the anterior-posterior axis in the CNS. Δmir larvae derepress a network of direct homeobox gene targets in the posterior ventral nerve cord (VNC), including BX-C genes and their TALE cofactors.

Benzyl-tris-[2-(di-benzyl-amino)-eth-yl]ammonium iodide.

In the title quaternary ammonium salt, C55H61N4 (+)·I(-), all three N,N-di-benzyl-ethanamine, -(CH2)2N(CH2C6H5)2, groups have different conformations. The N-C-C-N torsion angles are significantly different [89.86 (13), 162.

Characterization of an intermediate in the ammonia-forming reaction of Fe(DMeOPrPE)2N2 with acid (DMeOPrPE = 1,2-[bis(dimethoxypropyl)phosphino]ethane).

The reactivity of Fe(DMeOPrPE)2N2 with water and acid was explored. (DMeOPrPE is the bidentate phosphine 1,2-[bis(dimethoxypropyl)phosphino]ethane.) The complex reacts with acid to form trans-[Fe(DMeOPrPE)2(N2)H](+) and small amounts of ammonia and hydrazine.

Dichlorido(η(6)-p-cymene)(eth-oxy-diphenyl-phosphane)ruthenium(II).

The title compound, [RuCl2(C10H14)(C14H15OP)], is an Ru(II) complex in which an η(6)-p-cymene ligand, two chloride anions and the P atom of an ethoxydiphenylphosphane ligand form a piano-stool coordination environment about the central Ru(II) atom.

P,P'-Diphenyl-ethyl-enediphosphinic acid dihydrate.

The title compound, C(14)H(16)O(4)P(2)·2H(2)O, possesses a crystallographic inversion center where two -P(=O)(OH)(C(6)H(5)) groups are joined together via two -CH(2) groups. In the crystal, the acid molecules are linked by the water molecules via O-H⋯O hydrogen bonds, leading to the formation of a two-dimensional network lying parallel to (101).

Bis{1,2-bis-[bis-(3-meth-oxy-prop-yl)phosphan-yl]ethane-κP,P'}dichlorido-osmium(II).

In the centrosymmetric title compound, [OsCl(2)(C(18)H(40)O(4)P(2))(2)], the Os(II) atom adopts a trans-OsCl(2)P(4) geometry, arising from its coordination by two chelating diphosphane ligands and two chloride ions. One of the meth-oxy side chains of the ligand is disordered over two orientations in a 0.700 (6):0.

Coordination of a complete series of N2 reduction intermediates (N2H2, N2H4, and NH3) to an iron phosphine scaffold.

The series of dinitrogen reduction intermediates (N(2)H(2), N(2)H(4), and NH(3)) coordinated to the Fe(DMeOPrPE)(2)H(+)(DMeOPrPE = 1,2-[bis(dimethoxypropyl)phosphino]ethane) scaffold has been synthesized or generated. The synthesis of trans-[Fe(DMeOPrPE)(2)(NH(3))H][BPh(4)] and generation of trans-[Fe(DMeOPrPE)(2)(N(2)H(4))H][BPh(4)] were achieved by substitu tion of the dinitrogen ligand on trans-[Fe(DMeOPrPE)(2)(N(2))H][BPh(4)]. The trans-[Fe(DMeOPrPE)(2)(N(2)H(2))H](+) complex and its deprotonated conjugate base, trans-Fe(DMeOPrPE)(2)(N(2)H)H, were observed by (31)P and (1)H NMR from decomposition of trans-[Fe(DMeOPrPE)(2)(N(2)H(4))H](+) in the presence of excess hydrazine.

Reactions of coordinated hydroxymethylphosphines with NH-functional amines: the phosphorus lone pair is crucial for the phosphorus Mannich reaction.

Non-coordinated hydroxymethylphosphines react readily with primary and secondary amines by the phosphorus Mannich reaction. To determine if this reactivity can be used to synthesize phosphine macrocycles, trans-Fe(DHMPE)(2)Cl(2) (DHMPE = 1,2-bis(dihydroxymethylphosphino)ethane) was prepared and reacted with various amines. However, no phosphorus Mannich reactivity was observed.