Quantum Chemical Lipophilicities of Antimalarial Drugs in Relation to Terminal Half-Life.

According to the WHO, artemisinin-based combination therapies (ACTs) have been integral to the recent reduction in deaths due to malaria. ACT-resistant strains are an emerging problem and have evolved altered developmental stages, reducing exposure of the most susceptible stages to artemisinin drugs in popular ACTs. Lipophilicity, log , is a guide in understanding and predicting pharmacokinetic properties such as terminal half-life which alters drug exposure.