Microbes and Parkinson's disease: from associations to mechanisms.

Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number of microorganisms have been associated with increased risk of PD in humans, and recent research using newly developed models has begun to elucidate how these microbes may factor into disease development.

Characterization of the intestinal microbiota during infection in a mouse model of infection-triggered Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen resulted in the development of PD-like pathology in mice compared to wild-type littermates.

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1 mice.

Parkinson's disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to have key roles. An early-onset form of Parkinson's disease is associated with mutations in the PINK1 kinase and PRKN ubiquitin ligase genes.

High-pressure Injection Injuries of the Hand.

High-pressure injection hand injuries are often overlooked, with severe complications owing to the acute inflammatory response. Prognosis for depends on the type of material injected, location of injection, involved pressure, and timing to surgical decompression and debridement. Acute management involves broad-spectrum antibiotics, tetanus prophylaxis, emergent decompression within 6 hours, and complete removal of the injected material.

Pronator-sparing technique for volar plating of distal radius fractures.

Acute distal radius fractures are commonly treated by volar locking plate fixation and typically involve reflection of the pronator quadratus for adequate exposure of the fracture. Recently, attention has been centered on the role and repair of the pronator quadratus. This article presents an alternative approach to fixation of distal radius fractures with a pronator-sparing technique that offers similar short-term radiographic outcomes to the conventional volar plating approach.

Characterization of radiation exposure in early-onset scoliosis patients treated with the vertical expandable prosthetic titanium rib.

Background: The evaluation and treatment of patients with early-onset scoliosis requires multiple imaging studies and involves potential exposure to high cumulative lifetime doses of ionizing radiation. The Vertical Expandable Prosthetic Titanium Rib (VEPTR) used in the treatment of early-onset scoliosis requires numerous lengthening procedures and frequent radiographic follow-up. The purpose of this study was to quantify the ionizing radiation exposure in pediatric patients undergoing VEPTR treatment and to identify factors that place patients with early-onset scoliosis at greater risk of radiation exposure.