Publications by authors named "Tyler A Shugg"
Article Synopsis
- - The study investigates genetic factors that may predispose patients to acute kidney injury (ICI-AKI) when treated with immune checkpoint inhibitors (ICIs), which enhance the immune system's ability to fight cancer but can lead to adverse effects.
- - Researchers found that among cancer patients receiving ICIs, the incidence rate of AKI was significantly higher (23.2%) compared to a general cohort (6.5%), identifying the rs16957301 variant in the PCCA gene as a major risk factor for ICI-AKI in self-reported and ancestry-estimated Caucasians.
- - Self-reported Caucasians carrying the rs16957301 risk genotypes developed AKI approximately three months sooner than those with the reference
Patient Educ Couns
October 2023
Article Synopsis
- The study aimed to evaluate how well patients understood their CYP2C19 pharmacogenomic test results after cardiac procedures, given that prior research had not objectively measured this comprehension.
- Out of 31 patients interviewed, very few could identify the gene tested or their metabolizer status, with only 23% demonstrating "Adequate Understanding" of how their results might affect medication efficacy.
- The findings suggest that most patients lack even basic understanding of their test results, highlighting the need for better communication between healthcare providers and patients regarding pharmacogenomic testing.
