Publications by authors named "Txia Xiong"

Objective: To identify Hmong and Latino adults' perspectives about a mHealth-based care model for hypertension (HTN) management involving blood pressure (BP) self-monitoring, electronic transmission of BP readings, and responsive HTN medication adjustment by a provider team.

Design: We conducted a mixed-methods formative study with 25 Hmong and 25 Latino participants with HTN at an urban federally-qualified health center. We used a tool to assess HTN knowledge and conducted open-ended interviews to identify perspectives about mHealth-based care model.

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Individuals of distinct Asian backgrounds are commonly aggregated as Asian, which could mask the differences in the etiology and prevalence of health conditions in the different Asian subgroups. The Hmong are a growing Asian subgroup in the United States with a higher prevalence of gout and gout-related comorbidities than non-Hmong. Genetic explorations in the Hmong suggest a higher prevalence of genetic polymorphisms associated with an increased risk of hyperuricemia and gout.

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Background: Suboptimal treatment of hypertension remains a widespread problem, particularly among minorities and socioeconomically disadvantaged groups. We present a health system-based intervention with diverse patient populations using readily available smartphone technology. This intervention is designed to empower patients and create partnerships between patients and their provider team to promote hypertension control.

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Article Synopsis
  • Warfarin dosage is influenced by genetic factors, particularly in the Hmong population, which has been underrepresented in genetic research despite their distinct allele frequencies related to warfarin metabolism.
  • The study aims to validate these allele frequency differences in Hmong compared to East Asians and to analyze predicted warfarin sensitivity and maintenance doses.
  • Results show significant differences in allele frequencies for warfarin-related genes and indicate that Hmong individuals are more likely to be very sensitive to warfarin, requiring lower maintenance doses than their East Asian counterparts.*
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Article Synopsis
  • The study aimed to explore how genetic differences in very important pharmacogenes (VIPs) among Hmong individuals could impact medication choices and dosages, comparing them with East Asians.
  • 194 Hmong adults' DNA was analyzed for 22 genetic variants in 8 VIPs, with significant allele frequency differences identified in 23% of the tested variants.
  • These genetic variations are likely to result in tailored medication recommendations for the Hmong population that differ from those suggested for East Asians, particularly for drugs like warfarin, simvastatin, and phenytoin.
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