Publications by authors named "Twan Otten"
Article Synopsis
- The COVID-19 pandemic influenced population-level immune responses through infections, lockdowns, and vaccination efforts, potentially impacting various immune-mediated diseases.
- In a study of 1,895 asymptomatic individuals living with HIV, researchers assessed how these factors modified inflammatory profiles and immune responses between October 2019 and October 2021.
- Results showed that while mild COVID-19 infections had minimal long-term immune effects, lockdowns significantly increased immune responsiveness, and vaccinations moderately reduced it, suggesting lockdowns may have unexpected immunological consequences that warrant further investigation.
Background: We aimed to compare the non-AIDS events (nADE) risk between normal progressors using ART (NP-ART) and people with HIV (PWH) that naturally control HIV infection (HIV controllers), as well as the outcomes after ART in HIV controllers on nADE.
Methods: The primary endpoint was major nADE defined as the composite of cardiovascular disease, non-AIDS malignancy or all-cause mortality, whichever came first..
Article Synopsis
- Immunological non-responders (INR) are HIV patients with persistently low CD4+ T-cell counts despite effective antiretroviral therapy, putting them at higher risk for health issues.
- A study comparing INR to immunological responders (IR) found that INR had older age, more severe HIV prior to treatment, and lower CD4+ T-cell counts, with an increase in activated and exhausted CD4+ T-cells.
- The research highlighted that INR demonstrated impaired lymphocyte cytokine production, while innate immune responses remained similar, suggesting a potential benefit of anti-PD1 therapy for this group.
In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens.
View Article and Find Full Text PDFIntroduction: People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for application to larger cohorts, we compared multiple omics data layers.
Methods: Bulk and single-cell transcriptomics, flow cytometry, proteomics, chromatin landscape analysis by ATAC-seq as well as drug stimulation were performed in a small number of blood samples derived from PLHIV and healthy controls from the 200-HIV cohort study.
C-reactive protein (CRP) is used to discriminate common bacterial and viral infections, but its utility in tropical settings remains unknown. We performed a meta-analysis of studies performed in Asia and Africa. First, mean CRP levels for specific tropical infections were calculated.
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