Characterization of Deformational Isomerization Potential and Interconversion Dynamics with Ultrafast X-ray Solution Scattering.

Dimeric complexes composed of d square planar metal centers and rigid bridging ligands provide model systems to understand the interplay between attractive dispersion forces and steric strain in order to assist the development of reliable methods to model metal dimer complexes more broadly. [Ir (dimen)] (dimen = -diisocyanomenthane) presents a unique case study for such phenomena, as distortions of the optimal structure of a ligand with limited conformational flexibility counteract the attractive dispersive forces from the metal and ligand to yield a complex with two ground state deformational isomers. Here, we use ultrafast X-ray solution scattering (XSS) and optical transient absorption spectroscopy (OTAS) to reveal the nature of the equilibrium distribution and the exchange rate between the deformational isomers.

Orbital-optimized density functional calculations of molecular Rydberg excited states with real space grid representation and self-interaction correction.

Density functional calculations of Rydberg excited states up to high energy are carried out for several molecules using an approach where the orbitals are variationally optimized by converging on saddle points on the electronic energy surface within a real space grid representation. Remarkably good agreement with experimental estimates of the excitation energy is obtained using the generalized gradient approximation (GGA) functional of Perdew, Burke, and Ernzerhof (PBE) when Perdew-Zunger self-interaction correction is applied in combination with complex-valued orbitals. Even without the correction, the PBE functional gives quite good results despite the fact that corresponding Rydberg virtual orbitals have positive energy in the ground state calculation.

Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS-Results from an Open Label Study.

Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study.

Effect of anti-rheumatic treatment on selenium levels in inflammatory arthritis.

Objectives: The reason for increased cardiovascular risk in inflammatory arthritis (IA) is unclear. Interestingly, selenium-deficiency is suspected to contribute to the development of cardiovascular disease (CVD) in the general population. Although the reference range of serum selenium (s-selenium) is 50-120 μg/L, there are indications that levels up to 85 μg/L might not be sufficient for optimal cardioprotection.

Is perceived intolerance to milk and wheat associated with the corresponding IgG and IgA food antibodies? A cross sectional study in subjects with morbid obesity and gastrointestinal symptoms.

Background: Serum IgG and IgA food antibodies have been used for dietary advice to subjects with gastrointestinal symptoms and perceived food intolerance, but the role of these antibodies in mediating intolerance is controversial. The present study investigated associations between perceived gastrointestinal intolerance to milk-or wheat and the corresponding s-IgG and s-IgA food antibodies in subjects with morbid obesity.

Methods: Subjects with morbid obesity (BMI ≥ 40 kg/m or ≥35 kg/m with obesity-related complications) were included.

The Gut Microbiota and the Emergence of Autoimmunity: Relevance to Major Psychiatric Disorders.

Background: Autoimmune phenotypes are prevalent in major psychiatric disorders. Disequilibria of cellular processes occurring in the gastrointestinal (GI) tract likely contribute to immune dysfunction in psychiatric disorders. As the venue of a complex community of resident microbes, the gut in a homeostatic state equates with a functional digestive system, cellular barrier stability and properly regulated recognition of self and non-self antigens.

Peptides' role in autism with emphasis on exorphins.

Problem: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity.

Methods: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid-acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer.

Effect of Arnica D30 in marathon runners. Pooled results from two double-blind placebo controlled studies.

Objective: To examine whether the homeopathic medicine Arnica D30 has an effect on muscle soreness and cell damage after marathon running.

Methods: The subjects were 82 marathon runners from two separate randomised double-blind placebo controlled trials participating in the Oslo Marathon in 1990 and 1995. Five pills of Arnica D30 or placebo were given morning and evening.

Effect of homoeopathy on pain and other events after acute trauma: placebo controlled trial with bilateral oral surgery.

Objective: To examine whether homoeopathy has any effect on pain and other inflammatory events after surgery.

Design: Randomised double blind, placebo controlled crossover trial with "identical" oral surgical procedures performed on two separate occasions in 24 patients.

Interventions: Treatment started 3 hours after surgery with either homoeopathy or placebo.

[Homeopathy--the past or a part of future medicine?].

The exact mechanism for the effect of homeopathic remedies is still an enigma. Research shows in vitro effects of homeopathy, as well as differences between the effects of simple dilutions and so called homeopathic potencies. Some of the (relevant) publications are widely disputed.

[Effect of Arnica D 30 during hard physical exertion. A double-blind randomized trial during the Oslo Marathon 1990].

The effect of Arnica Montana on stiffness, restitution time and cell damage during hard physical exercise was evaluated in a randomized double blind trial during the Oslo Marathon. 36 participants were randomized: one group received Arnica 10(-30) five pills twice daily for five days, starting the day before the event. The other group received placebo pills.