Publications by authors named "Tuyoshi Tanabe"
Biomed Pharmacother
May 2009
Article Synopsis
- TOB (transducer of ErbB-2) is identified as a tumor suppressor that inhibits cell growth when introduced into NIH3T3 cells and has effects in pancreatic cancer cell lines.
- The study involved administering an adenoviral vector expressing the tob gene (Ad-tob) to pancreatic cancer cells, showing that transfection with this vector led to growth suppression in specific cell lines (SOJ and AsPC-1).
- In experimental models of pancreatic cancer peritonitis, Ad-tob treatment significantly reduced tumor growth and prevented complications, indicating its potential as a therapeutic option for chemotherapy-resistant pancreatic cancer.
