Publications by authors named "Tuya Wang"
Adenomatous polyposis coli (APC) is widely recognized as a heavily mutated gene that suppresses tumor growth in colorectal cancer (CRC). Its mutation is considered to be the primary and early event that occurs in the development of CRC. In addition, APC has a crucial role in inhibiting the canonical Wnt signaling pathway.
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- Gastric cancer (GC) has a poor prognosis and is characterized by aggressive development, prompting research into circular RNAs (circRNAs) as potential biomarkers and therapeutic targets, specifically hsa_circ_0008667.
- This study analyzed the expression of hsa_circ_0008667 in GC tissues and cells, finding it linked to lymph node metastasis and a higher tumor-node-metastasis stage, indicating a worse patient prognosis.
- The silencing of hsa_circ_0008667 suppressed GC cell growth and invasion, while also negatively regulating miR-9-5p, suggesting that hsa_circ_0008667 could serve as a valuable prognostic biomarker and tumor promoter in GC.
Adenomatous polyposis coli (APC), a well-known anti-oncogene, is considered to have multiple functions through its several binding domains. We have continuingly studied APC mice (APC1638T mice) to elucidate the functions of APC other than tumor suppression. A distinctive feature of the APC1638T mice is they are tumor free and live as long as APC mice (WT mice).
View Article and Find Full Text PDFThe adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth retardation.
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