Synthesis, In Silico Study, Antibacterial and Antifungal Activities of -phenylbenzamides.

Antibiotic and antifungal resistance problems have been prevalent in recent decades. One of the efforts to solve the problems is to develop new medicines with more potent antibacterial and antifungal activity. -phenylbenzamides have the potential to be developed as antibacterial and antifungal medicine.

Synthesis, ADMET predictions, molecular docking studies, and anticancer activity of some benzoxazines against A549 human lung cancer cells.

Objectives: This study aims to synthesize a series of benzoxazines (-) to be examined as an epidermal growth factor receptor (EGFR) inhibitor by study. The overexpression of EGFR causes the growth of normal lung cells to become uncontrollable, which may lead to cancer formation. We also conducted the absorption, distribution, metabolism, excretions and toxicity (ADMET) properties evaluation and also examined anticancer assay on human lung cancer cells line, which is A549.