A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1.

Patients with neurofibromatosis type 1 develop both benign and malignant tumors at an increased frequency. Most of the malignant peripheral nerve sheath tumors (MPNSTs) are considered as high-grade sarcomas originating from tissues of mesenchymal origin. It is generally accepted that MPNSTs occur in about 2% to 5% of neurofibromatosis patients.

Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs.

Objective: The aim of this study was to evaluate the effectiveness of systemic administration of resveratrol against cisplatin-induced ototoxicity in guinea pigs.

Materials And Methods: Healthy guinea pigs (n=24) were randomly divided into four groups. Group 1 (n=6) received resveratrol+cisplatin, group 2 (n=6) received 4% ethanol+cisplatin, group 3 (n=6) received cisplatin, and group 4 (n=6) received saline.

Effect of topical use of mitomycin C and 5-fluorouracil on the closure time of myringotomies created by radiofrequency unit.

Conclusion: Both mitomycin C (MC) and 5-fluorouracil (5-FU) had a significant effect in prolonging the patency rate of radiofrequency myringotomy.

Objective: To compare the effect of topical use of MC and 5-FU on the closure time of myringotomies created by a radiofrequency unit.

Materials And Methods: Myringotomies were performed using a radiofrequency unit on 80 tympanic membranes of 40 rats.

Ototoxic effect of topical ciclopirox as an antimycotic preparation.

Objective: To evaluate the ototoxicity of ciclopirox-containing solution as an otologic preparation for the treatment of otomycosis.

Background: Ciclopirox is a synthetic antimycotic agent available in a variety of formulations to treat superficial fungal infections. Ciclopirox has demonstrated both fungicidal and fungistatic activity in vitro against a broad spectrum of pathogenic fungi.

Ototoxic effect of Burow solution applied to the guinea pig middle ear.

Objective: To analyze the ototoxicity of Burow solution as an otologic preparation.

Background: Burow solution has been used for years in the treatment of acute or chronic otitis externa and chronic suppurative otitis media. This acidic solution has antibacterial and antiedematous properties.

The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo.

Objectives: The aims of the study were to determine: 1) how mucociliary activity in acute bacterial rhinosinusitis is affected; 2) how this activity is changed by therapy; 3) the effects of topical agents on mucociliary clearance, and 4) the most appropriate topical agent(s) to be used in the therapy of sinusitis.

Study Design: Five groups of patients with acute bacterial rhinosinusitis were studied prospectively.

Methods: All patients had 500 mg oral amoxicillin and 125 mg oral clavulanic acid preparations given three times daily for 3 weeks.

Prevalence of human papillomavirus (HPV) DNA in larynx and lung carcinomas.

In this retrospective study, we investigated the HPV DNA occurrence in 21 laryngeal and 26 primary lung squamous cell carcinomas. Nonisotopic in situ hybridization (NISH) technique was performed with commercially available digoxigenin-labelled DNA probes for HPV screening. Subtyping for HPV subtypes 6/11, 16/18 and 31/33 was also performed.

Clinical importance of supratubal recess in cholesteatoma surgery.

Objective: To determine the importance of supratubal recess in cholesteatoma surgery by presenting the clinical presentation, imaging findings, and surgical treatment methods of 66 patients with cholesteatoma. We propose that the management of supratubal recess allows the opportunity for total removal of the cholesteatoma with the prevention of recurrence.

Study Design: Retrospective review of surgical cases.

Endolymphatic sac tumor: a case report.

Papillary tumors of the temporal bone are aggressive neoplasms which may occur sporadically or as a part of von Hippel-Lindau disease. The term 'endolymphatic sac tumor' identifies the origin of these rare tumors. The clinical manifestations are sensorineural hearing loss, facial paralysis, cerebellar disorders and vertigo.

Cardiotoxicity of 5-flourouracil: two case reports.

Cardiotoxicity is a rare but serious side effect of 5-flourouracil (5-FU). The cardiotoxicity incidence of 5-FU is increasing with its frequent use in chemotherapy protocols. To explain the mechanism of this cardiotoxicity, many theories have been suggested by different authors.

The effect of endoscopic sinus surgery on mucociliary activity and healing of maxillary sinus mucosa.

The aim of this study was to determine histologic findings in the maxilaarysinus mucosa by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and ciliary activity within the nasal cavity by measuring the speed of mucociliary transport and after endoscopic sinus surgery (ESS). Thirty patients were enrolled. Thirty-eight antral mucosae of 24 24 patients were investigated according to ultrastructural changes and 6 patients were accepted as controls.

Effects of topical otic preparations on hearing in chronic otitis media.

Most of the topical otic preparations have been shown to cause ototoxicity. In this study ciprofloxacin hydrochloride, a relatively new topical agent, and gentamicin sulfate were studied in two groups of 20 patients with chronic otitis media. Patients were randomly selected to receive either ciprofloxacin (200 microg/ml) or gentamicin sulfate (5 mg/ml) locally, five drops three times a day for 10 days.

Treatment of chronic ear disease. Topical ciprofloxacin vs topical gentamicin.

Objective: To determine and compare the therapeutic efficiency of ciprofloxacin hydrochloride and gentamicin sulfate in the treatment of chronic ear disease.

Design: Prospective randomized study.

Setting: Academic tertiary medical center.

Squamous epithelium in the middle ear and sinus.

This study has been performed between December 1990-March 1991 in the Microsurgery laboratory of the Marmara University Hospital. Twelve healthy albino guinea pigs were used as a study group while the control group consists of three animals. The potentials for cholesteatoma formation of the squamous epithelium, namely the squamous epithelium of the posterior superior part of the external ear canal skin and normal skin, were investigated.

Hemangiopericytoma as the cause of Collet-Sicard syndrome.

Collet-Sicard syndrome is one of the jugular foramen syndromes in which the last four cranial nerves are involved whereas the sympathetic plexus is spared. It is very uncommon to find facial paralysis associated to this syndrome and most interestingly, a hemangiopericytoma at this location to cause all these paralyses. We have not been able to find a similar case in the literature, and thus present our case.