[About non-specific prophylaxis of infections typical for organized groups].

Respiratory tract infections and pyodermia are typical for personnel doing military service under conscription. Risk of progression of these infections is connected with activation of carry-over of causative agents among military personnel during replacement and decrease in immunity of conscripts. Usage of medication "Karmolis Kapli" for the purpose of prophylaxis allows to reduce cases of respiratory tract infections among the military personnel.

[Terminologic aspects of infections associated with administration of medical aid].

Evolution of key terms used in epidemiology of nosocomial infections is discussed. A modern point of view on terminology and comparison of Russian terms with foreign analogues are presented.

[Actual vitamin and main foodstuffs consumption by recovered patients suffered from hemorrhagic fever with renal syndrome].

Actual consumption of vitamins A, E, beta-carotene, ascorbic acid, thiamin, pyridoxine and main foodstuffs by recovered patients suffered from hemorrhagic fever with renal syndrome has been given. Frequency analysis of foodstuffs consumption was used to study actual nourishment of recovered patients. Surplus consumption of fat mainly due to the use of saturated fatty acids, deficiency of poly unsaturated fatty acids, surplus sugar consumption and predominance of proteins of animal origin over proteins of vegetable origin in ration has been revealed.

[Effect of imunofan on several indexes of immunity and pyoderma incidence among cadets of educational institutes].

It was discovered that during the first several months military service men have suppression of several indexes of immunity and a high level of morbidity by pyoderma. Was shown a high effectiveness of immunomodulatory agent Imunofan on correction of immunity status of servicemen and decrease of morbidity by pyoderma (more than on threefold): the effectiveness index is 3,25, the defense index is 69,2%. In addition, it was marked hepatitis- and stress-protect effect of the agent.

[Using regulatory peptide imunofan in type 2 diabetes mellitus patients with diabetic foot syndrome].

Aim: To potentiate the effect of basic therapy and to correct of immune dysfunction in type 2 diabetes mellitus (T2DM) patients with diabetic foot syndrome by using the immunoregulatory peptide imunofan.

Subjects And Methods: Sixty-nine T2DM patients with the diabetic foot and retinal angiopathy were examined. All the patients were randomized to 2 groups: study (n = 39) and control (n = 30) groups matched for clinical manifestations, age, gender, and the duration and severity of the disease.

[Mechanisms of inhibiting production of tumor necrosis factor alpha by the synthetic hexapeptide--immunophane].

The authors examined the human blood mononuclear-induced tumor necrosis factor production using the new drug--the synthetic hexapeptide Immunophan. The levels of tumor necrosis factor in the supernatant liquid were measured by the enzyme immunoassay and the cytotoxic test using L-929 fibroblastoid cells. Following 2-8 hours of short-term incubation of mononuclear cells with Immunophan, there was a reduction in spontaneous or lipopolysaccharide - or ionophore A23187-induced production of tumor necrosis factor.

[Tumor necrosis factor in patients with suppurative-septic complications in terminal states and the possibilities for correcting its production].

The authors review the results of study of tumor necrosis factor (TNF) production by mononuclears in 37 patients recovered after critical conditions of various genesis. Relationships between TNF production, condition severity and complications development have been established. Use of a new correcting agent thymogexin ensured a modulating effect and reduced an excessively high TNF production both in vitro and in patients with pyoseptic complications.

[Tumor necrosis factor and possibilities of correction of its production in patients with suppurative-septic complications in terminal states].

The production of tumor necrosis factor (TNF) by mononuclears was studied in 37 patients after critical states of various origins. A relationship was revealed between the TNF production and the patient's condition severity and the development of pyoseptic complications. Use of thymohexin, a new drug for correction, provided a modulating effect and helped reduce the excessively increased TNF production both in vitro and in the patients with pyoseptic complications.

[Genetic aspects of the action of immunosuppressive agents].

The data were obtained formerly that mice of certain strains essentially differ in the sensitivity to the immunodepressive and antiproliferative action of the alkylating agents (so-called opposite strains: DBA/2--highly sensitive, BALB/c--resistant). It is shown in the present work that with the use of the other non-alkylating immunodepressive agents (cytarabine, cyclosporin A, dexamethasone) that differ in the action mode, DBA/2 mice retain a high sensitivity whereas BALB/c mice a low sensitivity to all the immunodepressants. The sensitivity to the immunodepressive action in vivo directly correlates with that of the immunocompetent cells in vitro.