Clinical course and outcome of SARS-CoV-2 infection in multiple sclerosis patients treated with disease-modifying therapies - the Polish experience.

Introduction: The aim of this study was to report the course and outcome of SARS-CoV-2 infection in multiple sclerosis (MS) patients treated with disease-modifying therapies (DMTs) in Poland. A major concern for neurologists worldwide is the course and outcome of SARS-CoV-2 infection in patients with MS treated with different DMTs. Although initial studies do not suggest an unfavourable course of infection in this group of patients, the data is limited.

Real-world effectiveness of fingolimod in Polish group of patients with relapsing-remitting multiple sclerosis.

Objectives: Fingolimod is indicated for the treatment of relapsing-remitting multiple sclerosis (RRMS) patients with highly aggressive disease characterized by frequent relapses and active magnetic resonance imaging. Its efficacy has been demonstrated in three large phase III trials, used in the regulatory submissions throughout the world. Fingolimod in licensed in Europe since 2011 but with a growing number of disease-modifying drugs (DMD) becoming available for RRMS, it is important to gather real-world evidence data regarding long-term effectiveness in treated patients with MS.

Mechanical thrombectomy in acute stroke - Five years of experience in Poland.

Objectives: Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland.

Methods And Results: We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures.

[Early neurological complications after internal carotid endarterectomy].

Background And Purpose: Stenosis of internal carotid arteries is one of the leading causes of ischemic stroke. Surgical restoration of arterial patency is the primary therapeutic method, aimed to prevent future ischemic stroke. This treatment mode is mainly reserved for patients with recurrent stenoses of internal carotid artery.

[Leber's hereditary optic neuropathy (LHON) with mutation at G3460A and MS-like phenotype].

A sporadic case of a 31 year-old woman with genetically confirmed diagnosis of LHON was presented. Both her optic nerves were affected, with a 5-year interval between the onset in one eye and the loss of vision in the second one. Besides optic atrophy clinical and laboratory signs of multiple sclerosis were found.

[Electromyography monitoring in the treatment of torticollis with botulinum toxin].

Unlabelled: The new method of treatment chronic torticollis is injection into affected muscles botulinum's toxin. Some physicians in diagnostic procedure, treatment and monitoring use needle electromyography (nEMG). The aim of our study was the estimation of the value of nEMG in chronic torticollis treatment.

[Neurological disorders of vitamin B12 deficiency].

It is almost two hundred years since the description of the first neurological disorders in vitamin B12 deficiency. In spite of that, not all the aspects of the biological effect of the vitamin have been explained. It is well known, that the vitamin performs an important function in organic metabolism and two types of biochemical reactions depend on it.

[Acute intermittent porphyria: actual problems of clinical and laboratory diagnosis].

On the case of 27 old woman with clinical symptoms of acute abdomen, severe electrolyte disturbances and attacks of grand mal seizures, different clinical masks and actual treatment guidelines of acute intermittent porphyria are presented. Among laboratory methods detecting precursors of hem in the urine, high-performance liquid chromatography (HPLC) as the most sensitive and specific method is recommended. Proper prophylaxis against new episodes of acute intermittent porphyria as well as long lasting ambulatory care of the patient are emphasized.

[Subarachnoid hemorrhage due to conus medullaris ependymoma].

A case of conus medullaris tumour (ependymoma) is reported in which the presenting symptom was subarachnoid haemorrhage, which has left bladder dysfunction. 70-year-old patient was admitted to the Department of Neurology due to symptoms of conus medullaris lesion with retention of urine and diminished pain sensitivity in perianal zona. He had been hospitalized 30 years ago due to vomiting, headache and pain in lumbar region.

[Neurologic signs in Addison-Biermer disease (report of 3 cases)].

The authors report three patients in whom a neurological syndrome was the first manifestation of Addison-Biermer disease. In the first case a paraneoplastic neurological syndrome was suspected, in two other cases the initial tentative diagnosis was multiple sclerosis. The correct diagnosis was reached after a prolonged diagnostic procedure and after ruling out of other diseases.

[Hyperkalemic periodic paralysis or congenital paramyotonia: an attempt of treatment with phenytoin].

Authors describe 2 patients with hyperkalemic period paralysis where positive therapeutic effect was achieved after treatment with phenytoin. They compare the features of paramyotonia congenital with hyperkalemic period paralysis and they think that they are the same disease with different clinical signs.

[2 cases of Fahr's disease].

The authors describe two cases of Fahr's disease--idiopathic cerebral calcification.