TRPV4 facilitates the reprogramming of inflamed macrophages by regulating IL-10 production via CREB.

Background: Transient receptor potential vanilloid type 4 (TRPV4) is a versatile ion channel with diverse roles in immune cells, including macrophages. While its function in inflammation remains debated, we investigated its role in regulating IL-10 production and its impact on macrophage reprogramming during inflammation.

Methods: We investigated the connection between TRPV4 activation and CREB-mediated IL-10 production during inflammation.