Publications by authors named "Tushar Vachharajani"

A functional vascular access (VA) is of paramount importance to patients on hemodialysis therapy. While arteriovenous fistula (AVF) remains the preferred VA, their long-term patency is unpredictable. A dysfunctional VA contributes to a high morbidity rate, an increased susceptibility to major adverse cardiovascular events, recurrent hospitalization, and a poor quality of life.

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  • - Insertion of a peritoneal dialysis (PD) catheter in patients with end-stage renal disease (ESRD) and liver cirrhosis is difficult, often leading to complications like ascitic fluid leaks that disqualify them from PD.
  • - A case study involving three ESRD patients with tense ascites who underwent large volume fluid drainage alongside hemodialysis found that they had a challenging lifestyle due to multiple medical procedures each week.
  • - To prevent leaks after PD catheter insertion, the study suggests using a continuous drainage system for about two weeks post-surgery before beginning PD training, which resulted in successful healing without complications.
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  • Non-tunneled dialysis catheters (nTDCs) are commonly used for dialysis in ICU patients, and if they need dialysis for more than two weeks, they can either be replaced or switched to tunneled dialysis catheters (TDCs).
  • This study aimed to assess the safety and effectiveness of placing TDCs and other tunneled central venous catheters (tCVCs) using anatomical landmarks instead of the standard fluoroscopic guidance.
  • Out of 111 catheters placed using this technique, 110 had the correct tip placement, with few major complications, although a significant number (18 out of 111) were placed in patients who did not
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Aim: Kidney biopsy (KB) is the gold standard procedure for diagnosing kidney diseases. Globally, nephrologists are trained to perform KB. However, the past few decades have witnessed a transition where interventional radiologists (IRs) are now preferentially performing the procedure.

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  • The study focuses on improving blood transfusion strategies for critically ill patients with liver disease undergoing central venous catheter placement, aiming to reduce reliance on allogeneic blood products and complications associated with bleeding and thrombosis.
  • Researchers compared the effectiveness of a thromboelastography-guided approach to a conventional strategy, assessing outcomes in volume, units, and cost of blood products used during transfusions.
  • Findings show that the thromboelastography-guided group received significantly fewer units and lower total volumes and costs of transfused blood products, with no increase in bleeding or thrombotic complications observed.
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Aim: Vascular and peritoneal access are essential elements for sustainability of chronic dialysis programs. Data on availability, patterns of use, funding models, and workforce for vascular and peritoneal accesses for dialysis at a global scale is limited.

Methods: An electronic survey of national leaders of nephrology societies, consumer representative organizations, and policymakers was conducted from July to September 2018.

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  • A curriculum was developed to enhance procedural access for internal medicine residents through an interdisciplinary procedure course featuring simulation sessions and a one-week rotation supervised by various medical specialties.
  • Sixteen residents participated, resulting in nearly double the number of procedures performed (from 176 to 343) and significant increases in confidence levels, especially for intubations.
  • The collaboration across specialties proved effective in boosting residents' procedural skills and confidence, highlighting their desire for improved training opportunities.
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Aim: This cross-sectional survey aimed to determine the prevalence of Interventional Nephrology (IN) practice amongst nephrologists in the Asia-Pacific Region (APR), specifically related to dialysis access (DA).

Methods: The Association of VA and intervenTionAl Renal physicians (AVATAR) Foundation from India conducted a multinational online survey amongst nephrologists from the Asia-Pacific to determine the practice of IN in the planning, creation, and management of dialysis access. The treatment modalities, manpower and equipment availability, monthly cost of treatment, specifics of dialysis access interventions, and challenges in the training and practice of IN by nephrologists were included in the survey.

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The perspective of vascular access care in patients with end-stage renal disease has migrated from nephrology-centered or vascular surgery-centered care to multidisciplinary-focused patient-centered care. This new perspective should not only be theoretical but also have practical utility. A non-multidisciplinary focus can contribute to the low prevalence of arteriovenous fistula (AVF) in the population.

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The development of vascular access for hemodialysis has come a long way since 1943 when the first hemodialysis treatment was performed in humans by connecting an artery and vein using an external glass canula. Since then, vascular access care has evolved robustly through contributions from numerous countries and professional nephrology societies, worldwide. To understand the global distribution and contribution of different specialties to medical literature on dialysis vascular access care, we performed a literature search from 1991 to 2021 and identified 2768 articles from 74 countries.

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Hemodialysis remains the most frequently chosen kidney replacement modality across the world. A well-functioning dialysis vascular access is critical to providing successful dialysis therapy. Despite its drawbacks, central venous catheter is commonly used as a vascular access to initiate hemodialysis therapy in acute and chronic settings.

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  • - This report analyzes electronic health record (EHR) data from a major US health system to highlight the unmet needs of patients dealing with type 2 diabetes and chronic kidney disease.
  • - It identifies key opportunities to improve patient management by focusing on treatment protocols, screening processes, monitoring practices, and the efficient use of healthcare resources.
  • - The findings aim to guide healthcare providers in better supporting this specific patient population and enhancing their overall care experience.
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Background: Treatment of end-stage kidney disease (ESKD) with hemodialysis requires surgical creation of an arteriovenous (AV) vascular access-fistula (AVF) or graft (AVG)-to avoid (or limit) the use of a central venous catheter (CVC). AVFs have long been considered the first-line vascular access option, with AVGs as second best. Recent studies have suggested that, in older adults, AVGs may be a better strategy than AVFs.

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Rationale And Objective: This study aimed to develop a cosmesis scale to evaluate the cosmetic appearance of hemodialysis (HD) arteriovenous (AV) accesses from the perspective of the patient and clinician, which could be incorporated into clinical trials.

Study Design: Using a modified Delphi process, two AV access cosmesis scale (AVACS) components were developed in a four-round Delphi panel consisting of two surveys and two consensus meetings with two rounds of patient consultation.

Setting And Participants: The Delphi panel consisted of 15 voting members including five interventional or general nephrologists, five vascular surgeons, three interventional radiologists, and two vascular access nurse coordinators.

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  • A validated measure of vascular access (VA) function is essential for effective hemodialysis (HD), but currently, there is no reliable method to assess this outcome in clinical practice.
  • The VALID study aims to evaluate the accuracy and feasibility of measuring VA function using a defined standard over a 6-month period, comparing routine clinical assessments to expert evaluations.
  • The study will include approximately 612 participants from diverse dialysis units across multiple countries, focusing on gathering data on the effectiveness, time, and acceptability of the VA function measurement process.
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Rationale & Objective: The incidence and prevalence of patients with kidney failure requiring dialysis are increasing in Pakistan. However, in-depth perspectives on kidney care from Pakistani people requiring maintenance dialysis are lacking.

Study Design: Qualitative interview study.

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Background: The COVID-19 pandemic has adversely affected health care systems and dialysis access care in the US and across the globe. Beyond the initial challenges posed by the pandemic and despite the actions taken by health care leaders/organizations/professional societies such as the "Maintaining Lifelines for ESKD Patients" joint statement, there continues to be delays in providing timely care and performing elective and emergent dialysis access procedures worldwide. The aim of this study was to assess the global challenges associated with providing dialysis vascular access care across the international vascular access community during the pandemic.

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Objective: To explore the feasibility and safety of Guidewire-Balloon Entrapment Technique (GBET) for the recanalization of thoracic central vein occlusions (TCVOs) in hemodialysis patients.

Methods: A retrospective observational study was conducted using data from 28 patients who required the establishment or maintenance of hemodialysis access and were treated with GBET for the recanalization of right-sided TCVOs from January 2017 to April 2021. Of the patients, 27 required tunneled cuffed catheter (TCC) placement or exchange, and 1 had an outflow tract occlusion of the Brescia-Cimino radio cephalic arteriovenous fistula (AVF).

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