Publications by authors named "Tushar Sahay"
Article Synopsis
- The cytokine TWEAK and its receptor Fn14 are linked to tumor growth and are elevated in cancer, leading to complications like cachexia (muscle and weight loss).
- Research showed that targeting Fn14 with antibodies can significantly increase lifespan in cancer patients by minimizing muscle and fat loss, even though it only moderately affects tumor size.
- Fn14's role in inducing cachexia is primarily through tumor signaling, as tumors in mice lacking Fn14 had similar cachexia symptoms to those with functional Fn14, suggesting Fn14 antibodies could be a valuable treatment for cachexia in cancer.
