[The experience with the use of neuromedin preparations for the treatment of sensorineural impairment of hearing].

The objective of the present study was to evaluate the effectiveness of the application of neuromedin for the treatment of sensorineural loss of hearing of different etiology. A total of 230 patients at the age varying from 20 to 60 years presenting with sensorineural impairment of hearing were available for the observation. Neuromedin was administered intramuscularly at 15 mg/day (1.

[The effect of the laser irradiation of the blood on its lipid and phospholipid components in diabetes mellitus].

Study results of the laser irradiation impact on the blood lipid and phospholipid components and membrane erythrocyte in patients with diabetes mellitus and pyo-necrotic injuries of lower extremities when treated by laser intravenously or epicutaneously. The results prove, that the laser irradiation of low intensity favourably affects the blood components in a complex treatment of diabetes mellitus. Intravenous irradiation positive dynamics are more easily observed.

Distribution of the total unsaturation in lipid components of plasma as a new differential diagnostic method in clinical analysis.

Using ozonization and thin-layer chromatographic methods we determined the qualitative and quantitative correlation of unsaturation distribution (UD) in individual fractions of blood plasma lipids in children suffering from insulin-dependent diabetes mellitus (IDDM). The research was aimed at elucidation of biochemical criterion of the degree of metabolic disorders in children with IDDM and at development of methods for quantitative assessment of such disorders. Twenty children were examined during the compensation stage (group 1), and twelve during decompensation with ketoacidosis (group 2).

[Use of electron paramagnetic resonance in assessing viscosity of blood lipids in diabetes mellitus in children].

Viscosity of blood serum lipids was studied in children with insulin-dependent diabetes involving nitroxyl containing probes-registered by means of radiospectrometer RE 1307. The following parameters were studied: the ratios between values exhibiting the probe distribution in polar and hydrophobic phases [formula: see text] as well as between content of low polar (I+1) and high polar (I-1) spectral components. The "f' value showed the state of lipid density and the ratio [formula: see text] allowed to estimate the lipid microviscosity.

[Distribution of the total quantity of fatty acid double bonds in lipid components of the blood in children with diabetes mellitus].

Children suffering from insulin-dependent diabetes mellitus (IDDM) were examined for unsaturation, that is, total quantity of double bonds in individual fractions of blood serum lipids was assessed. Lipid fractions were isolated by thin-layer chromatography. Unsaturation was assessed by ozonation method.

[Microcirculatory hemostasis in children with insulin-dependent diabetes mellitus].

Study of microcirculatory hemostasis in children with insulin-dependent diabetes mellitus helped the authors to make new conclusions on metabolic changes underlying blood coagulation cellular factors, namely, the red cell and platelet levels. Fifty children aged 7 to 15, suffering from type I condition, were examined. Ten of these were examined during the compensation stage, 23 during decompensation without ketosis, and 17 with ketoacidosis.

[The indices of the lipid peroxidation and desaturation of the blood serum in diabetes mellitus in children].

Comparative investigation of indices of lipid peroxidation and blood lipid unsaturation was carried out in 91 pediatric inpatients (aged 7 to 15) with type I diabetes mellitus and in 10 controls of the same age. Activation of free radical lipid peroxidation was shown to occur in children with diabetes mellitus. A degree of compensation of diabetes did not influence the level of hydroxyperoxides (HP) and final decay products (FP) of lipid peroxidation.

[Comparative aspects of the changes in lipid metabolism indicators in lymphocyte and erythrocyte membranes in children with diabetes mellitus].

Lipid metabolism in lymphocytes was compared to that in the blood serum and red blood cells. 50 children aged 7 to 15 years suffering from insulin-dependent diabetes mellitus (IDDM) in the phase of decompensation without ketosis were examined. The patients were treated at hospital.

[Study of unsaturated plasma lipids in children with diabetes mellitus].

The determination of unsaturation of lipids contained by the blood serum and cell plasma membranes, which depends on the total amount of double bonds (DB) in unsaturated fatty acids is a new and promising method of estimating lipid metabolism in diabetes mellitus. Unsaturation was determined by ozonization. 91 children aged 7 to 15 years were examined.

[Effect of long-term space flight on erythrocyte metabolism and the function of the erythrocyte membrane].

This paper presents the data about red blood cell metabolism and the structure and function of erythrocyte membranes obtained from two cosmonauts after their 326- and 160-day flights. In both cases we observed inhibition of energy formation (decrease of the rate of glycolysis and ATP content) and enhancement of oxidative processes (decrease of reduced glutathione and activity of antioxidative enzymes). The above changes in the metabolic status of erythrocytes are correlated with shifts at the membrane level, particularly with variations of membrane lipids, phospholipid spectrum and ratios of phospholipid fractions, alteration of membrane-bound enzymes (ATPase) and increase of cell resistance to acid hemolysis.

[Changes in the lipid composition of the lymphocyte membranes and in the reactions of the lymphocytic Fc receptors in obesity].

The paper is concerned with a study of a response of lymphocytic Fc receptors (FcR) to modulators regulating their expression (prostaglandins E2 and F2, 2 X 10(-9) M, isoproterenol 10(-5), 10(-6) M) as compared to changes in the lymphocyte membrane lipid composition of patients with obesity of II-III degree with a high blood cholesterol level up to 9-10 nmol/l. Two groups were distinguished among obese patients: "areactive" in which lymphocytic FcR did not respond to modulators, and "reactive" in which FcR responded at least to one of 4 utilized modulators. Research into the lipid spectrum of lymphocytic membranes revealed a significant decrease in the concentration of nonesterified fatty acids in membranes of "areactive" lymphocytes to 4 +/- 0.

[Comparative evaluation of the lipid metabolic indices of children with a hereditary predisposition for diabetes and in manifest diabetes mellitus].

The paper is concerned with the results of investigation of serum lipid, phospholipid and lipoprotein spectra in 31 sibs, 100 children with diabetes mellitus (DM), 83 women in birth with DM and their fetuses. This study showed a necessity of planned investigation of sibs not only for the detection of glucose tolerance but also of primary and secondary dyslipemia. In children with manifest DM the ratio of lipid, phospholipid and lipoprotein fractions was disturbed and depended upon a degree of compensation, a period of disease and a dose of insulin.

[Diet therapy of hyperlipidemia in children].

A classification of hyperlipidemias (HLP) in children has been presented in which the main types and forms of the disease are described. The general principles of the diet therapy in children with HLP have been formulated. It is stressed that the ration should include the products containing lipotropic substances, and possessing anticholesterol properties.

[Indices of the lipid spectrum of the blood serum and erythrocyte membranes in diabetes mellitus in children].

The paper is concerned with the results of a comparative study of the blood serum lipid spectrum and erythrocytic membranes in 100 children with diabetes mellitus aged 7 to 15 and 20 healthy children of the same age. The ratio of lipid and lipoprotein fractions depending on a degree of compensation, duration of disease and the presence of complications was disturbed in the blood serum and erythrocytic membranes of the diabetic children. The recovery of lipid metabolism was delayed as compared to clinical convalescence of the patients, therefore appropriate correcting therapy was required.

[Effect of diet therapy on indicators of lipid metabolism in obese children].

The effects of staged, readaptation dietetic management on the time course of changes in the body weight and lipid metabolism were studied in 40 children aged 10-15 years with constitutional exogenous obesity, stages II and III. It was based on a progressive metabolic readaptation of the sick body. Analysis of the data obtained indicates that dietetic management produces different effects in obese children, which attests to the gravity of metabolic disorders in overweight.