Therapeutic vaccination in the immunotolerant phase of children with chronic hepatitis B infection.

Aim: Hepatitis B virus (HBV) infection is a major global health concern and is the most common cause of chronic liver disease worldwide. Our aim was to investigate the efficacy of specific HBV vaccination as active immunotherapy in treating chronic hepatitis B (CHB) infection during the immunotolerant phase of children with normal aminotransferase values and high viral load.

Materials And Methods: Seventy-four patients never vaccinated before were randomly and prospectively recruited into two groups.