Publications by authors named "Turgay N"

Article Synopsis
  • Hepatocellular carcinoma (HCC) is a major global health issue often diagnosed late, making early detection critical yet difficult.
  • This study utilizes deep learning with the You Only Look Once (YOLO) architecture to improve HCC detection in CT images, using a dataset of 1290 images from 122 patients.
  • The YOLO model achieved impressive diagnostic results, with a precision of 0.97216, recall of 0.919, and overall accuracy of 95.35%, indicating its potential to enhance early diagnosis and patient outcomes in clinical settings.
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Objective: Each year, approximately 125 million people visit malaria-endemic countries. This study aimed to investigate the clinical characteristics of imported malaria infections in Türkiye.

Methods: The study included patients diagnosed with malaria between 1996 and 2022.

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Objective: Monitoring intestinal parasite frequencies is effective on diagnosis, treatment, and prevention strategies to be developed against these parasites. In this study, it was aimed to reveal the parasite species and frequency data of stool samples in parasitology direct diagnosis laboratory.

Methods: Stool parasitological examination results were obtained retrospectively from our laboratory internal quality control data tables.

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In this study, we aimed to perform a biosafety risk assessment to determine measures to be taken against coronavirus disease 2019 (COVID-19) in the routine diagnostic parasitology laboratory of a tertiary health care center. The risk assessment template included in the supplement of the interim guidance of "WHO Laboratory Biosafety Guidance Related to COVID-19" was used for the risk assessment. Risk assessments were carried out for the "diagnosis of protozoan diseases in respiratory tract samples" and "diagnosis of intestinal parasitic diseases" processes.

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Article Synopsis
  • * The study involved five isolates from chronic CL patients, using real-time PCR for genotyping and drug efficacy tests to evaluate the effectiveness of miltefosine and meglumine antimoniate against the disease.
  • * Results indicated that miltefosine effectively killed the promastigotes at specific concentrations, and since there are few studies on miltefosine's effects on CL patients, further research is recommended to enhance treatment strategies for this condition.
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Objectives: Leishmaniasis is a vector-borne disease and dogs may act as urban reservoirs. Turkey and most of the Mediterranean basin countries are endemic for leishmaniasis. In this study, it is aimed to report the autochthonous leishmaniasis cases, with all the components of the infection cycle (reservoir, vector, and the host) in a region close to Europe.

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Objective: Because the protocols used in the treatment of leishmaniasis can be toxic and have many limitations, such as the development of resistance against such protocols, new treatment options are needed, especially against resistant patients. models may be a good source for evaluating new drug options for patients with antimony-resistant parasites. This study aimed to evaluate the Glucantime concentration for our glial cell amastigote model we had defined in previous work.

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Article Synopsis
  • Cutaneous Leishmaniasis (CL) is mainly categorized into acute and chronic forms, with this study focusing on the efficacy of miltefosine compared to pentavalent antimony in treating chronic CL using mouse models infected by a patient sample.
  • The study involved three groups of mice, with one receiving miltefosine, one receiving meglumine antimoniate, and one serving as a control, all monitored for footpad swelling over 24 weeks.
  • Results indicated that miltefosine led to a significant reduction in footpad swelling compared to the control, and while there was no significant difference between miltefosine and meglumine antimoniate, miltefosine showed
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Objective: Scabies is diagnosed based on the presence of burrows on the skin, scabiei adult, egg, or scybala in skin scrapings. The laboratory diagnosis of scabies poses various challenges. We aimed to compare the analytical performance of skin scraping and standard superficial skin biopsy (SSSB) and to investigate the correlation with false negative results in the laboratory diagnosis of scabies.

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Intestinal protozoan parasites are common causes of infectious diarrhea in children receiving anticancer therapy or undergoing transplantation. Additionally, immunosuppression therapy in such patients may exacerbate the symptoms related to these parasitic infections. The aim of this study was to evaluate the prevalence and diagnostic importance of parasitic protozoan infections in children treated for malignancies or undergoing transplantation, and to highlight the control of intestinal parasitic infections for immunosuppressed patients at a hospital in İzmir, Turkey.

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Article Synopsis
  • Laboratories play a crucial role in patient care, and evaluating their performance is essential for ensuring accurate results, especially since most errors occur in the pre-analytical phase outside the lab.
  • The six-sigma method and quality indicators are key tools for identifying errors, improving process quality, and meeting international standards for laboratory safety and efficiency.
  • A study at Ege University aimed to assess the pre-analytical performance of its Parasitology Direct Diagnosis Laboratory using historical data and established quality targets, with a goal sigma level of 4.6.
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The frequency of bronchopulmonary protozoan infections has raised due to increased number of immunosuppressed patients in recent years. One of them is which is a multi-flagellated protozoan parasite of termites and several cockroach species. The drug regimens commonly used in bronchopulmonary infections are not effective against .

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Objective: Blastocystosis has been linked with non-specific symptoms, such as diarrhea, abdominal pain, and distention. In this study, we evaluated the relationship between Blastocystis spp. with urticaria and intestinal symptoms.

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Objective: Intestinal parasitic infections are common in immunodeficient patients. In developing countries, the incidence of diarrhea due to parasitic infections in HIV (human immunodeficiency virus)-positive individuals is reported to be over 90%. The present study aimed to investigate the presence of intestinal protozoa in HIV-positive patients with gastrointestinal complaints.

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Article Synopsis
  • The study examines the effect of Cytomegalovirus (CMV) co-infection on mortality rates in non-HIV patients with Pneumocystis jirovecii pneumonia (PCP).
  • Of 43 patients studied, 65.1% had confirmed CMV co-infection, and those with CMV had higher rates of complications like ARDS and longer ICU stays.
  • While initial findings suggested a higher mortality rate in the CMV co-infection group, further analysis indicated that mortality was primarily linked to ARDS rather than CMV itself, highlighting the need for better PCP prophylaxis awareness among physicians.
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Background: Myiasis complication of diabetic foot ulcer has only been presented in a few case reports. Therefore, there is a need for additional data on this infestation.

Objective: Evaluate clinical characteristics of human myiasis in patients with diabetic foot.

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Leishmaniasis is a vector-borne zoonotic disease that shows different clinical features like cutaneous, mucocutaneous, visceral and viscerotropic forms. The protocols used in the treatment of leishmaniasis are toxic and have many limitations during administration. One of the limitations of treatment is the resistance against the protocols in practice.

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Malaria is a widespread and life-threatening disease in tropical and subtropical regions. In patients with typical clinical symptoms, malaria is considered as a preliminary diagnosis if there is a travel history to malaria-endemic areas. The basis of the laboratory diagnosis of malaria is the microscopic examination of Giemsa stained smears.

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Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are seen endemically in Turkey and CL caused by Leishmania tropica is an important public health problem in southeastern as well as other regions of Turkey. The diagnosis has been usually made by clinical view of lesion and/or parasitologically using lesion aspiration smears. Histological examination does not, always reveal the parasite in the skin biopsy, particularly in chronic lesions.

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Introduction: Pneumocystis jirovecii pneumonia (PCP) causes serious infections, especially in patients with immunosuppressive diseases. In this study, it was aimed to evaluate the results of samples obtained from PCP suspected patients using two different methods together with clinical data.

Materials And Methods: Microscopy and real time polymerase chain reaction (real time PCR) methods were performed with bronchoalveolar lavage (BAL) samples sended to Ege University Medical Faculty Direct Parasitology Diagnostic Laboratory between March 2009 and June 2010.

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Article Synopsis
  • * International travel has surged, with over 1.13 billion travelers in 2014, increasing exposure to infections like Zika and Ebola, particularly as travelers take more risks in developing and exotic regions.
  • * Despite its significance, travel medicine is often overlooked as a critical field, similar to the study of parasitic diseases.
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Objective: Parasites might cause atypical and severe infections in immunocompromised hosts. The prevalence of diarrhea among common variable immune deficiency (CVID) syndrome patients varies between 20% and 94%, which indicates that diarrhea and gastrointestinal system (GIS) complaints could be the second leading cause of morbidity in CVID patients after respiratory tract infections. This study aimed to assess the prevalence of intestinal parasites in CVID patients with GIS complaints and diarrhea.

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Clinicians have usually considered malignancies during follow up of patients who have infectious diseases as a pre-diagnosis. However, malignancy and an infectious disease are seen together more rarely, with the exception of immunosuppressed patients. This presentation is a case report followed up for fever of unknown origin.

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The 17-year-old male patient presented with fever, weakness, dyspnea and weight loss. His chest radiography demonstrated diffuse reticulonodular density, and high-resolution lung tomography indicated diffuse micronodules and prevalent ground-glass pattern. The findings were consistent with miliary involvement.

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