Determination of Carrier Frequency of Actionable Pathogenic Variants in Autosomal Recessive Genetic Diseases in the Turkish Cypriot Population.

Whole-exome DNA sequencing is a rich source of clinically useful information for specialists, patients, and their families, as well as elucidating the genetic basis of monogenic and complex diseases in clinical diagnosis. However, interpreting and reporting variants encompassing exome and genome sequence analysis outcome data are one of the greatest challenges of the genomic era. In this study, we aimed to investigate the frequency and allele frequency spectrum of single nucleotide variants accepted as recessive disease carrier status in Turkish Cypriot exomes.

Strong Association between Vitamin D Receptor Gene and Severe Acute Respiratory Syndrome coronavirus 2 Infectious Variants.

A coronavirus disease 2019 (COVID-19) disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created significant concern since December 2019 worldwide. The virus is known to be highly transmissible. Heterogenic clinical features even vary more among SARS-CoV-2 variants from asymptomatic forms to severe symptoms.

Does Type of Pharyngeal Packing during Sinonasal Surgery Have an Effect on PONV and Throat Pain?

Objective: Postoperative nausea and vomiting (PONV) is a common problem that affects up to 30% of all surgical patients after general anaesthesia, which increases in sinonasal surgery due the very potent emetic effect of ingested blood that is swallowed during the procedures. Therefore, a hypo/oropharyngeal packing is commonly placed in an effort to prevent blood ingestion. The primary aim of this study was to compare the efficacy of 3 packing types in preventing PONV and to compare the results with patients who received no packing.

Effectiveness of online education in teaching breast self- examination.

Background: This research evaluated the effectiveness of an online education model in teaching breast self- examination to university staff and students.

Materials And Methods: 1,679 women participated in a breast self-examination online training program. Breast self-examination knowledge evaluation forms developed by Maurer (1997) were used in the research and were evaluated on a 100 point scale.

Determination of knowledge of Turkish midwifery students about human papilloma virus infection and its vaccines.

Human papilloma virus (HPV) is one of the most common sexually transmitted agents and its infection is the most established cause of cervical cancer. Midwives play a key position in the implementation of cervical cancer. This descriptive study aimed to determine the level of knowledge concerning HPV and HPV vaccination among 268 midwifery students.

Lifespan persistence of ADHD: the life transition model and its application.

Background: The understanding that attention-deficit/hyperactivity disorder (ADHD) often persists throughout life has heightened interest of patients, families, advocates, and professionals in a longitudinal approach to management. Such an approach must recognize and address known patient- and systems-based challenges of long-term mental health treatment, shifting of clinical presentations of ADHD, and commonality of psychiatric comorbidity with ADHD.

Objective: The ADHD Life Transition Model is a step toward developing criteria to optimize recognition and clinical management of ADHD (eg, response, remission) across an individual's lifespan and across diverse medical subspecialties.

Cigarette dependence among males and females aged 50+ living in Izmir, Turkey.

Background: Smoking, the most important preventable cause of death overall, is also the leading cause of cancer-related mortality. Tobacco consumption has a direct or indirect relationship with most types of cancer. In Turkey, the second leading cause of death is cancer, with lung cancer the most prevalent.

Research activities and perceptions of barriers to research utilization among Turkish nurses.

Background: This study assessed the barriers to the use of research in nursing practice among Turkish registered nurses.

Methods: A descriptive cross-sectional study of 718 nurses in three hospitals was conducted. The data collection instrument used for the study consisted of the Barriers to Research Utilization Scale and a self-administered questionnaire that included demographic data, educational background, and nurses' involvement in research activities.

Time courses of improvement and symptom remission in children treated with atomoxetine for attention-deficit/hyperactivity disorder: analysis of Canadian open-label studies.

Background: The relatively short durations of the initial pivotal randomized placebo-controlled trials involving atomoxetine HCl for the treatment of attention-deficit/hyperactivity disorder (ADHD) provided limited insight into the time courses of ADHD core symptom responses to this nonstimulant, selective norepinephrine reuptake inhibitor. The aim of this analysis was to evaluate time courses of treatment responses or remission, as assessed by attainment of prespecified scores on the ADHD Rating Scale-IV-Parent Version: Investigator Administered and Scored (ADHDRS-IV-PI) and the Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) scales, during up to 1 year of atomoxetine treatment in children with ADHD.

Methods: Using pooled data from three Canadian open-label studies involving 338 children ages 6-11 years with ADHD who were treated with atomoxetine for 3, 6 and 12 months, and survival analysis methods for interval-censored data, we estimated the time to: 1) improvement and robust improvement defined by ≥25% and ≥40% reductions from baseline ADHDRS-IV-PI total scores, respectively; and 2) remission using two definitions: a final score of ADHDRS-IV-PI ≤18 or a final score of CGI-ADHD-S ≤2.

Do Turkish nursing and midwifery students teach breast self-examination to their relatives?

Aim: To describe health beliefs and breast self-examination (BSE) practice of Turkish female nursing and midwifery students and assess teaching of BSE to their mothers, sisters, relatives.

Methods: The study was designed as a definition survey, withe data obtained from 113 participants, in third and fourth class and their mothers, sisters, relatives in Turkey. Data were collected by using a personal data form, knowledge evaluation form for BSE (Maurer 1997) and the Champion's Health Belief Model Scale.

Executive function deficits in children with attention-deficit/hyperactivity disorder and improvement with lisdexamfetamine dimesylate in an open-label study.

Objective: To assess the effects of lisdexamfetamine dimesylate (LDX) on executive function (EF) behaviors in children with attention-deficit/hyperactivity disorder (ADHD).

Methods: This observational, open-label, 7-week, dose-optimization study of LDX (20-70  mg/day) in children with ADHD evaluated efficacy with the ADHD Rating Scale IV; safety measures included adverse events (AEs). EF was assessed with the Behavior Rating Inventory of Executive Function (BRIEF).

Clinically relevant changes in emotional expression in children with ADHD treated with lisdexamfetamine dimesylate.

Objective: To describe clinically relevant effects of lisdexamfetamine dimesylate (LDX) on emotional expression (EE) in children with ADHD.

Method: Children with ADHD participated in a 7-week, open-label, LDX dose-optimization study. Expression and Emotion Scale for Children (EESC) change scores were analyzed post hoc using two methods to determine proportion of participants with different categories of clinical response based on (a) clinically significant (movement >2 SD from baseline mean)/reliable change (not due to measurement error) and (b) standard error of measurement (SEM) as a measure of clinically meaningful change.

'Stepped procedure' in laparoscopic cyst decortication during the learning period of laparoscopic surgery: Detailed evaluation of initial experiences.

Background: We evaluated the importance and efficacy of 'stepped procedure' in laparoscopic cyst decortication as an initial experience in it.

Materials And Methods: A 36 renal cyst cases were included. The stepped retroperitonoscopic cyst excision divided into three groups.

Relations between breast and cervical cancer prevention behaviour of female students at a school of health and their healthy life style.

Regular breast self-examination (BSE) and pap-smear tests are the two of the positive heath behaviors for improving, promoting and protecting the health of adolescent girls. The present quasi-experimental research was carried out with the purpose of analyzing the relations between breast and cervical cancer prevention behavior of female students at a School of Health and their health lifestyle. The research was conducted at Canakkale Onsekiz Mart University School of Health between November 2008 and February 2009.

Effectiveness of the auscultatory and pH methods in predicting feeding tube placement.

Aims And Objectives: This study was designed to determine the effectiveness of the auscultatory and pH methods in predicting feeding tube location in critically ill patients.

Background: There is confusion about how nurses should asses feeding tubes location at the bedside. The most common method for determining tube location is the auscultatory method.

Effects of peer education, social support and self esteem on breast self examination performance and knowledge level.

Objective: To estimate associations among peer education, social support and self-esteem and their influences on performance of breast self-examination (BSE).

Method: Seven volunteer peer educators were given the BSE training programme and in turn educated 65 women students in the university. BSE knowledge evaluation forms developed by Maurer were applied for evaluation.

Complementary and alternative medicine used by pediatric patients with cancer in western Turkey.

Purpose/objectives: To determine the extent of complementary and alternative medicine (CAM) use, the types of therapies employed, and the reasons for choosing those therapies.

Design: Descriptive type, cross-sectional.

Setting: Pediatric oncology department in western Turkey.

Physical restraint use in Turkish intensive care units.

Objective: This study aimed to determine intensive care nurses' reasons for the application and removal of physical restraint and physical restraint patterns used in Turkey intensive care units.

Design: This research was conducted using descriptive and cross-sectional research design.

Setting: Data were collected in intensive care units of the 2 university hospitals and the 5 state hospitals in Izmir, West Turkey.

Investigation of attention deficit and hyperactivity disorder in adult patients with atopic dermatitis.

Background. Atopic dermatitis (AD) is a common chronic inflammatory disease that is associated with significant psychosocial morbidity and a decrease in health-related quality of life. Attention deficit hyperactivity disorder may be present in atopic dermatitis patients.

Psychopharmacological treatment of oppositional defiant disorder.

Oppositional defiant disorder (ODD) consists of an enduring pattern of uncooperative, defiant and hostile behaviour toward authority figures that does not involve major antisocial violations and is not accounted for by the developmental stage of the child. The rate of ODD in children and adolescents in the general population has been reported to be between 2% and 16%. The International Classification of Diseases 10th Revision (ICD-10) classifies ODD as a mild form of conduct disorder (CD), and it has been estimated that up to 60% of patients with ODD will develop CD.

Effect of the first chemotherapy course on the quality of life of cancer patients in Turkey.

Multiple studies have examined the quality of life of cancer patients before or after treatment, but few have evaluated the impact of a specific course of treatment on cancer patients' quality of life. Using a longitudinal design, we examined the quality of life of 24 women and 8 men before receiving their initial course of chemotherapy and again at 21 days after the first course of chemotherapy. The study was carried out at the outpatient chemotherapy unit of a university hospital located in the city of Izmir, West Turkey.