Investigating chemical diversity: -propargylphenols as key compounds in the divergent synthesis of 2-substituted benzofurans and chromenes.

In this study, we explored and optimized a MW-enhanced divergent approach for the synthesis of 2-substituted benzofurans and chromenes, starting from seventeen substituted -propargylphenols characterized by a monoaryl substitution on the propargylic sp carbon. Firstly, we developed a robust platform for the preparation of a library of -propargylphenols. Under basic conditions, -propargylphenols reacted regioselectively to yield benzofurans in yields ranging from 43% to 100%.

[Thrombocytosis and neonatal subcutaneous adiponecrosis].

The authors report three newborns with subcutaneous fat necrosis, that appeared between the 4th and 21st day of life. The infants, full term of normal weight, presented severe perinatal hypoxia and needed primary resuscitation. Severity and duration of perinatal hypoxia were not related with the time of cutaneous lesion onset.

Bone mass in young patients with type I diabetes.

We measured bone mineral content (BMC) with single photon absorptiometry in two groups of young patients with type I diabetes: the first group (prospective study) consists of 48 patients followed from onset to the third year of diabetes and the second group (cross-sectional study) consists of 66 long-term diabetics. Bone mineral content at onset of disease was lower than normal in only two cases. After 3 years of diabetes no male revealed BMC below the normal range but two females (6.