Publications by authors named "Turazza F"

Proximal humerus fractures account for approximately 3 to 5% of all pediatric-adolescent fractures, with a higher incidence observed in older children, particularly between the ages of 10 and 15 years. Non-displaced or minimally displaced fractures can often be treated conservatively. However, the management of displaced or unstable proximal humerus fractures in adolescents may involve surgical intervention, with closed reduction and percutaneous pinning (CRPP) being commonly employed techniques.

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  • Immunotherapy has improved cancer treatment, resulting in many patients experiencing long-term survival or even cures.
  • There is evidence suggesting that immune checkpoint inhibitors, which help fight cancer, may worsen atherosclerosis and increase the risk of cardiovascular issues due to shared molecular mechanisms and chronic inflammation.
  • Due to the rise in cancer patients receiving immunotherapy, it is crucial to understand the potential cardiovascular risks associated with treatment and implement preventative measures to address atherosclerosis-related complications.
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  • Atrial fibrillation (AF) is a common issue in cancer patients, and this study aims to evaluate their clinical characteristics and management, particularly focusing on antithrombotic medications.
  • The study involved 1,514 patients with recent cancer diagnoses and confirmed AF, finding high rates of cardiovascular diseases and a significant number of patients not receiving optimal anticoagulation treatment upon admission.
  • Results indicate a significant underuse of appropriate antithrombotic therapy, suggesting the necessity for improved cardiovascular assessments in the care of cancer patients with AF.
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Tarsal coalition is an abnormal bony, cartilaginous, or fibrous bridge between 2 or more tarsal bones. Adolescent athletes with tarsal coalitions typically present with symptoms that include foot and/or ankle pain and limited range of motion. Loss of mobility can lead to abnormal loading, articular instability, deformity, and joint degeneration.

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Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven by the buildup of lipid-rich plaques within arterial walls, has emerged as a pivotal factor in the intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked by shared risk factors and pathophysiological mechanisms, underscores the need for a comprehensive understanding of how these two formidable health challenges intersect and influence each other. Cancer and its treatments can contribute to the progression of atherosclerosis, while atherosclerosis, with its inflammatory microenvironment, can exert profound effects on cancer development and outcomes.

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  • Cancer significantly increases the risk of developing atrial fibrillation (AF), prompting a study (BLITZ-AF Cancer) to gather data on antithrombotic drug usage in affected patients for better care management.
  • Conducted across six European countries, the study enrolled 1,514 patients, revealing a diverse range of underlying health conditions and cancer types; 41.5% had high CHA2DS2-VASc scores indicating a higher stroke risk.
  • Findings showed a notable increase in the use of direct oral anticoagulants (DOACs) among patients, suggesting a shift in treatment approach by cardiologists from traditional therapies like vitamin K antagonists to newer alternatives.
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  • Cardio-oncology rehabilitation (CORE) helps cancer patients stay healthy by focusing on their heart health while also dealing with cancer treatment effects.
  • It includes things like exercise, nutrition, and mental support to help patients avoid heart problems caused by cancer therapies.
  • More people need to use CORE, and it’s important for doctors and caregivers to work together to ensure the best care for cancer survivors.
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Introduction: our aim was to evaluate the clinical outcomes and complications of anterior tibialis tendon transfer (ATTT) in children with dynamic supination after clubfoot treatment.

Material And Methods: children with dynamic supination after initial treatment with Ponseti method or surgery who underwent ATTT between 2008 and 2020 were included for evaluation. Demographic data, previous treatment, associated procedures and fixation method were analyzed.

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Introduction: The increasing survival of patients with breast cancer has prompted the assessment of mortality due to all causes of death in these patients. We estimated the absolute risks of death from different causes, useful for health-care planning and clinical prediction, as well as cause-specific hazards, useful for hypothesis generation on etiology and risk factors.

Materials And Methods: Using data from population-based cancer registries we performed a retrospective study on a cohort of women diagnosed with primary breast cancer.

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  • - Atrial fibrillation (AF) is common in cancer patients, who experience it at higher rates than the general population, and the two conditions may influence each other.
  • - The causes of AF in cancer patients include inflammation, cancer treatments, and surgical procedures, which complicate their management.
  • - Treating cancer patients with AF involves standard strategies for rhythm control, but challenges like interaction with chemotherapy and underrepresentation in anticoagulant research create significant hurdles.
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This study aimed to describe the femoral groove morphology using ultrasound in children under 6 months, estimate the incidence of trochlear dysplasia, and evaluate associated risk factors. A prospective study included 298 patients who underwent universal ultrasound screening for hip dysplasia [developmental dysplasia of the hip (DDH)] and knee ultrasound. Measurements of sulcus angle (SA), trochlear depth (TD), and trochlear facet asymmetry (TFA) were analyzed.

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  • Recent advancements in percutaneous treatments for heart conditions have led to increased radiation exposure for interventional cardiologists, raising concerns about associated health risks like cancer and neurodegenerative disorders.
  • *The general lack of awareness among operators about their radiation exposure risk, coupled with ineffective preventive measures, highlights a significant safety issue.
  • *The ANMCO position paper aims to raise awareness among operators and propose strategies to reduce radiation doses and the associated health risks.*
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In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onset cancer therapy-related cardiovascular toxicity (CTR-CVT); (2) Patients with long-term control of not-curable cancers in whom CTR-CVT may need to be addressed. This paper highlights the importance of the cancer care continuum, of a patient-centered approach and of a prevention-oriented policy.

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Background/aim: There is controversy around the use of high-sensitive troponin T (hs-TnT) as an early biomarker of cardiac toxicity in patients with breast cancer on trastuzumab (T).

Patients And Methods: Patients receiving adjuvant or neo-adjuvant T for early HER2-positive breast cancer were prospectively included. Transthoracic echocardiograms and matched hs-TnT before T and at 3, 6, and 9 months were performed on all patients.

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Background: Baseline cardiovascular risk factors correction is recommended in all cancer patients undergoing potentially cardiotoxic therapies. Despite available guidelines, real-world data on dyslipidemia prevalence and management in the oncologic population are still sparse.

Methods: This survey was an Italian, investigator-initiated survey initially designed and drafted by the Cardio-Oncology section of the Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), comprising 10 individual multi-choice questions and spread after validation through the ANMCO mailing list.

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As cardio-oncology imposed itself as the reference specialty for a comprehensive cardiovascular approach to all patients with cancer, a more specific and careful cardiac evaluation of women entering their journey into cancer care is needed. Gender medicine refers to the study of how sex-based biological and gender-based socioeconomic and cultural differences influence people's health. Gender-related aspects could account for differences in the development, progression, and clinical signs of diseases as well as in the treatment of adverse events.

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Fractures about the knee are common in children and adolescents. Characteristics of the growing skeleton make children susceptible to specific fractures that do not occur in adults. Understanding the relevant anatomy, pathophysiology, diagnosis, and treatment options are important to decrease the risk of complications.

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Geriatric patients are an increasing population and cancer treatment in this population is a challenging and unsolved issue. Ageing is characterized by low-grade inflammation (inflamm-ageing), an important driver for age-related diseases such as cardiovascular diseases and cancer. These chronic conditions share pathophysiological bases, risk factors and may coexist.

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Overview of the meeting The Cardio-Oncology Symposium at the Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Annual Meeting mainly focused on the diagnosis, management and prevention of cardiovascular toxicity of cancer drugs, in particular, cardiac dysfunction induced by anthracyclines. Although a variety of cardiac biomarkers and imaging modalities are available, there remains no consensus regarding their appropriate use to identify early and late cardiotoxicity and to guide preventive strategies. At the same time, the multitude of pharmacological trials, aimed at preventing cardiac damage through a neurohormonal blockade, provided conflicting results.

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The pathophysiology of some non-communicable diseases (NCDs) such as hypertension, cardiovascular disease (CVD), diabetes, and cancer includes an alteration of the endothelial function. COVID-19 is a pulmonary and vascular disease with a negative impact on patients whose damaged endothelium is particularly vulnerable. The peculiar SARS-CoV-2-induced "endothelitis" triggers an intriguing immune-thrombosis that affects both the venous and arterial vascular beds.

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Radiotherapy may cause valvular (VHD), pericardial, coronary artery disease (CAD), left ventricular dysfunction (LVD), arrhythmias. The risk of radiation induced heart disease (RIHD) increases over time. The current guidelines suggest a screening for RIHD every 5 years in the long-term survivors who had been treated by chest RT.

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