[Evaluation of amixine reactivity and efficacy for prophylaxis of acute respiratory tract infections].

Amixine reactivity and tolerability were evaluated in controlled trial at the risk group of medical personal at the period of flu and respiratory viral infection season. Drugs safety was estimated according to anamnesis, direct observation and hemogram. High efficacy of the drug for the infections prophylaxis and treatment was demonstrated.

[Evaluation of amyxin effect in prophylaxis of acute respiratory viral infections].

The results of the evaluation of the oral inductor of endogenic interferon (amyxin), manufactured in Russia are presented. The use of amyxin was found to produce a drop in morbidity in acute respiratory virus infections (ARVI) among medical workers 3.4 times, i.

[The clinical manifestations, diagnosis and treatment of diphtheria in adults].

Diphtheria morbidity among adult population of Moscow is growing. The tests of different modes and schemes of heterogeneous antidiphtheria serum administration have found out that the highest efficacy of serotherapy was achieved with a single intravenous dose. Another treatment of diphtheria is hemosorption.

[Use of immunoenzyme analysis in the rapid diagnosis and study of the characteristics of circulating O-antigen in biological fluids of patients with acute dysentery Sonne].

The data on the clinical approval of the original enzyme immunoassay system for the determination of somatic O-antigen in the blood serum and urine of patients with acute Sonne dysentery are presented. The level of the antigen determined in the biological fluids of patients has been shown to depend on the severity of the disease. Different types of dynamic curves, reflecting the level of O-antigen in the biological fluids of patients with acute Sonne dysentery and characteristic of different clinical forms of the disease, have been established.

[An immunoenzyme method for determining the O-antigen of Sonne's shigella with the use of affinity isolated antibodies].

The sensitivities of ELISA systems for assays of Shigella sonnei O-antigen, developed on the basis of specific rabbit antibodies isolated from antisera by different chromatography techniques have been compared. The highest specificity and sensitivity of O-antigen determination (0.5-1 ng/ml) is achieved when using affinity-isolated antibodies to O-antigen.

[Free-radical oxidation of blood plasma lipids in patients with acute intestinal infections].

Blood plasma free radical lipid oxidation was studied in 98 patients with acute dysentery (AD) and 64 patients with food toxinfection (FTI). Free radical lipid oxidation was assessed by the intensity of chemiluminescence and the level of lipid peroxides. Activation of blood plasma lipid peroxidation was established with relation to a clinical variant of the disease.

[Effect of indomethacin on the daily catecholamine excretion and on the rheographic and capillaroscopic indices of salmonellosis patients].

A total of 127 patients with salmonellosis were studied for the effect of the disease severity on the central and peripheral hemodynamics, and catecholamine excretion. Introduction of indomethacin into a complex of treatment measures resulted in a more rapid recovery of the parameters of the central and peripheral hemodynamics and made catecholamine excretion return to normal.

[The role of prostaglandins in the pathogenesis of the Shwartzman phenomenon].

Schwartzman's phenomena, namely local and generalized reactions (SLR and SGR) were reproduced in two groups of rabbits weighing 1.5-2.5 kg.

[Role of arachidonic acid in platelet aggregation induced by S. typhimurium endotoxin].

The platelet aggregation reaction was used to assess the influence of arachidonic acid (AA), endotoxin (E) S. typhimurium and ADP on platelet aggregation properties. All the three substances induced platelet aggregation.

[Changes in the nephron and neuroendocrine apparatus of the kidneys following the administration of Salmonella endotoxin].

Electron microscopy was used to examine renal glomerules and tubules, as well as the renal neuro-endocrine apparatus 3 and 24 hours after intravenous injection of 2 mg/kg S. typhimurium endotoxin. The studies demonstrated swelling and vacuolization of the endothelial cells and an increase in the glomerular capillaries of the number of polymorphonuclear leukocytes with lysosomal sequestration and fibrin emergence 3 hours after endotoxin injection, intravascular coagulation, accumulation of polymorphonuclear leukocytes in the peritubular capillaries, fat dystrophy of the mesangial cells and nephrocytes in the proximal tubules after 24 hours.