Histological changes in parts of foregut of rat after indomethacin administration.

Background: Indomethacin, a non-steriodalanti-inflammatory drug, is used mainly for the treatment of painful joints such as rehumatoid arthritis, osteo-arhtritis, gout, ankylosing spondylitis etc. It relieves pain, reduces swelling and tenderness of the joints. It also induces ulceration of stomach and small intestine both in experimental animals and humans.