Dietary supplementation use for outpatient treatment in children: A cross-sectional study.

Objective: Dietary supplements (DSs) are commonly used supplements among children to support disease treatment, however, overuse and inappropriate prescription of outpatient DS can negatively affect health and treatment costs. This study aimed to evaluate DS use in outpatient treatment in children.

Methods: The present study used a cross-sectional descriptive retrospective method based on data from 188,579 outpatient prescriptions of children for 1 year.

and antihypertensive, anti-inflammatory, and analgesic activities of Del. leaf extracts.

(VA) leaves contain many potential active ingredients and exhibit diverse pharmacological activities. The antihypertensive, anti-inflammatory, and analgesic effects of VA crude and fraction extracts were carried out using Swiss albino mice models. VAE is considered safe to be administered due to LD being greater than 10,000 mg/kg body weight.

Evaluation of children's antibiotics use for outpatient pneumonia treatment in Vietnam.

Objective: Antibiotic resistance is increasing globally, associated with many failures in pneumonia treatment. This study aimed to evaluate antibiotic use in children treated for outpatient CAP (Community-Acquired Pneumonia).

Methods: A cross-sectional descriptive retrospective study was conducted, focusing on data from outpatient prescriptions for pneumonia in patients aged 2‒192 months in 2019‒2021.

Acute and sub-acute toxicity evaluation of Merremia tridentata (L.) stem extract on mice.

The acute and sub-acute toxicity studies were performed in male and female Swiss albino mice as per the guidelines mentioned in OECD. The oral administration of M. tridentata stem extract (MSE) showed no treatment-related mortality and body weight change in mice up to the single dose of 30,000 mg/kg body weight in the acute toxicity study and up to a dose of 30,000 mg/kg/day body weight in the sub-acute toxicity study.

,2,6-Trisubstituted 1-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, evaluation, and studies.

Compounds containing benzimidazole moiety occupy privileged chemical space for discovering new bioactive substances. In continuation of our recent work, 69 benzimidazole derivatives were designed and synthesized with good to excellent yields of 46-99% using efficient synthesis protocol sodium metabisulfite catalyzed condensation of aromatic aldehydes with -phenylenediamines to form 2-arylbenzimidazole derivatives followed by -alkylation by conventional heating or microwave irradiation for diversification. Potent antibacterial compounds against MSSA and MRSA were discovered such as benzimidazole compounds 3k (2-(4-nitrophenyl), -benzyl), 3l (2-(4-chlorophenyl), -(4-chlorobenzyl)), 4c (2-(4-chlorophenyl), 6-methyl, -benzyl), 4g (2-(4-nitrophenyl), 6-methyl, -benzyl), and 4j (2-(4-nitrophenyl), 6-methyl, -(4-chlorobenzyl)) with MIC of 4-16 μg mL.

In vitro and in vivo antidiabetic activity, isolation of flavonoids, and in silico molecular docking of stem extract of Merremia tridentata (L.).

The antidiabetic activity of stem-ethanol extract (SE) and the flavonoid-rich fraction (FF) of Merremia tridentata (L.) were investigated on alloxan-induced diabetic mice. Apigenin, cosmosiin, and quercitrin are flavonoids isolated for the first time from stem extracts.