Expected impact of MRI-related interreader variability on ProScreen prostate cancer screening trial: a pre-trial validation study.

Background: The aim of this study is to investigate the potential impact of prostate magnetic resonance imaging (MRI) -related interreader variability on a population-based randomized prostate cancer screening trial (ProScreen).

Methods: From January 2014 to January 2018, 100 men aged 50-63 years with clinical suspicion of prostate cancer (PCa) in Helsinki University Hospital underwent MRI. Nine radiologists individually reviewed the pseudonymized MRI scans of all 100 men in two ProScreen trial centers.

Asthma as aetiology of bronchiectasis in Finland.

Background: By definition bronchiectasis (BE) means destructed structure of normal bronchus as a consequence of frequent bacterial infections and inflammation. In many senses, BE is a neglected orphan disease. A recent pan-European registry study, EMBARC, has been set up in order to better understand its pathophysiology, better phenotype patients, and to individualize their management.

Simultaneous Comparison of Two Roller Compaction Techniques and Two Particle Size Analysis Methods.

A new dry granulation technique, gas-assisted roller compaction (GARC), was compared with conventional roller compaction (CRC) by manufacturing 34 granulation batches. The process variables studied were roll pressure, roll speed, and sieve size of the conical mill. The main quality attributes measured were granule size and flow characteristics.

Transport of particle-associated elements in two agriculture-dominated boreal river systems.

Transport of particulate pollutants in fluvial systems can contribute greatly to total loads. Understanding transport mechanics under different hydrological conditions is key in successful load estimation. This study analysed trace elements and physico-chemical parameters in time-integrated suspended sediment samples, together with dissolved and total concentrations of pollutants, along two agriculture- and peatland-dominated boreal river systems.

Past and future seasonal variation in pH and metal concentrations in runoff from river basins on acid sulphate soils in Western Finland.

Drainage of acid sulphate soils (ASS) increases oxidation, leading to extensive leaching of acidity and metals to rivers (Al, Cd, Cr, Fe, Ni and Zn). This is often apparent during high runoff periods in spring and autumn after long dry periods with low groundwater levels and associated ASS oxidation. Regression models were used to study changes in these water quality variables according to various discharge scenarios.

Long-term trends and variation of acidity, COD(Mn) and colour in coastal rivers of Western Finland in relation to climate and hydrology.

High acidity caused by geochemical processes and intensive land use of acid sulphate (AS) soils have continuously degraded the status of water bodies in Western Finland. Despite this, research on the long-term pattern and dynamics of acidification in rivers affected by acid sulphate soils is scarce. This study examined changes in alkalinity and pH value during the period 1913-2007 in nine large Finnish rivers discharging into the Gulf of Bothnia.

Non-Hodgkin lymphoma response evaluation with MRI texture classification.

Background: To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

Methods: A total of 19 patients having NHL with an evaluable lymphoma lesion were scanned at three imaging timepoints with 1.5T device during clinical treatment evaluation.