Publications by authors named "Tuo-Kan Talaf"
Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway.
Int J Clin Exp Pathol
September 2015
Article Synopsis
- Abnormal aquaporin (AQP) expression, particularly AQP8, has been linked to the progression of human cancers, including esophageal cancer.
- The study explored how epidermal growth factor (EGF) affects AQP8 expression and cell migration in esophageal cancer Eca-109 cells, demonstrating that EGF significantly enhances both AQP8 levels and cell movement.
- Inhibition of EGFR signaling through specific inhibitors like PD153035 and U0126 notably reduced EGF-induced AQP8 expression and cell migration, highlighting the role of the EGFR/ERK1/2 pathway in these processes.