In-silico study of novel dimeric flavonoid (OC251FR2) isolated from the seeds of Heckel () against alpha estrogen receptor (ER-α) of breast cancer.

Unlabelled: Estrogen hormone dependence accounts for a major cause in the incidence of women breast cancer. ER- is the major ER subtype in the mammary epithelium and plays a critical role in breast cancer progression. Tamoxifen (1-[4-(2-dimethylaminoethoxy)-phenyl]-1,2- diphenylbut-1(Z)-ene) is a nonsteroidal antiestrogen prodrug which formed pharmacologically active metabolite, 4-hydroxytamoxifen, largely used for endocrine therapy in pre and postmenopausal women with ER-positive breast cancer.