The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers.

Objective: In view of the fact that cancer patterns in patients with Parkinson disease (PD) differ from the general population, we aimed to verify whether patients with PD with LRRK2 mutations have an increased risk for particular cancer types.

Methods: In this cross-sectional study, eligible consenting Jewish patients with PD were genotyped for the predominant LRRK2 G2019S mutation. Oncologic data were obtained by personal interview and reviewing patients' files.

Gender effect on time to levodopa-induced dyskinesias.

Levodopa-induced dyskinesias (LID) are commonly observed during long-term treatment of patients with Parkinson's disease (PD). The impact of non-pharmacological factors on the latency to LID appearance is not known. The aim of the paper was to identify factors associated with time to appearance of LID.

Neuropsychiatric and cognitive features in autosomal-recessive early parkinsonism due to PINK1 mutations.

Autosomal-recessive early-onset Parkinsonism (AREP) due to PINK1 mutations is characterized by an early-onset, slowly progressive disease, with a good response to levodopa. Psychiatric and cognitive disturbances associated with AREP have rarely been reported in the literature. We describe 2 brothers from a Jewish-Iraqi consanguineous family with a homozygous PINK1 nonsense mutation.

[Age-related characteristics of the natural cytotoxicity system in patients with multiple sclerosis and their possible relation to the pathogenesis of the disease].

A study was made of the cytotoxic activity of natural killers (NK) against 3H-uridine labeled K-562 cells and its variability. 56 patients suffering from multiple sclerosis (MS), 33 healthy donors of different age and 34 patients with remitting MS and MS of different standing were entered into the study. The most remarkable lowering of the NK activity was seen in patients aged 41 to 50 years.

[Interferon-producing and cytotoxic activity of natural killer cells in multiple sclerosis patients].

Examination of 22 patients with multiple sclerosis (MS) has revealed a decrease in the cytotoxic activity of natural killer cells (NKC), in the production of endogenic interferon (EI) in the system of NK--target cells, and in the production of alpha- and gamma-interferon by stimulated lymphocytes. Some patients showed dissociation of the cytotoxic and interferon-producing activity of NKCs. Possible mechanisms responsible for changes in NKC activity are discussed.

[Experience in using T-activin in multiple sclerosis patients].

Forty patients with multiple sclerosis of a differing course, duration and severity were treated in this series. T-activin was employed as an immunocorrective agent (AFT-6 fraction). The immunological status was assessed in all patients observed prior to, during and after the treatment.

[Clinico-electrophysiologic, immunologic and biochemical studies of multiple sclerosis patients].

Immunological blood indices, neutral lipid fractions, level of daily urine C21-corticosteroid excretion, free amino acid spectrum of the blood were studied in 72 patients with disseminated sclerosis. The EEG, EMG and REG data were analyzed. Healthy persons of the same age formed the control group.

[Role of immunoregulatory cells and natural killers in the pathogenesis of multiple sclerosis].

Simultaneous investigations of the immunoregulatory cells and the natural killers were carried out in patients with different stages of multiple sclerosis in an attempt to determine a relationship between these organisms and the clinical stage of the disease. The quantities of E- and EAC-RFC in patients of all groups were within normal. The amount of T gamma-cells was decreased in the progressive phase of the disease and was significantly higher than normal during remission.